Home Antibody All anti-HLA-DMB antibodies
Also for HLA-DMB (NM_002118)
|Synthetic peptide contain a sequence corresponding to a region within amino acids 199 and 263 of Human HLA-DMB|
|0.1M Tris, 0.1M Glycine, 10% Glycerol (pH7). 0.01% Thimerosal was added as a preservative.|
|Purified by antigen-affinity chromatography.
|Homo sapiens major histocompatibility complex, class II, DM beta (HLA-DMB)|
Entrez Gene 3109 Human
|HLA-DMB belongs to the HLA class II beta chain paralogues. This class II molecule is a heterodimer consisting of an alpha (DMA) and a beta (DMB) chain, both anchored in the membrane. It is located in intracellular vesicles. DM plays a central role in the peptide loading of MHC class II molecules by helping to release the CLIP (class II-associated invariant chain peptide) molecule from the peptide binding site. Class II molecules are expressed in antigen presenting cells (APC: B lymphocytes, dendritic cells, macrophages). The beta chain is approximately 26-28 kDa and its gene contains 6 exons. Exon one encodes the leader peptide, exons 2 and 3 encode the two extracellular domains, exon 4 encodes the transmembrane domain and exon 5 encodes the cytoplasmic tail. [provided by RefSeq]|
|Transmembrane Cell adhesion molecules (CAMs)Antigen processing and presentationType I diabetes mellitusAsthmaAutoimmune thyroid diseaseSystemic lupus erythematosusMore Pathways >> |
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Western Blot analysis of HLA-DMB expression in transfected 293T cell line by HLA-DMB polyclonal antibody at 1:500 dilution.
Immunohistochemical analysis of paraffin-embedded Colon ca, using HLA-DMB antibody at 1:250 dilution.