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Home Antibody All anti-HIRA antibodies

Anti-HIRA Antibody EPR7416

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Specifications Citations (0) Related Products Product Documents
SKU Description Amount Price Availability*  
TA310575
  • Rabbit Monoclonal antibody against HIRA
100ul $325 3-7 Days
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WB(1)
IF(1)
Assay(1)

OriGene Data

ImmunogenA synthetic peptide corresponding to residues in human HIRA was used as an immunogen.
Clone NameEPR7416 IsotypeIgG
Species ReactivityHuman (Does not react with: Mouse, Rat) ConcentrationLot dependent; please refer to CoA along with shipment
Guaranteed Application *WB, ASSAY, IF Suggested DilutionsWB: 1:1000 - 1:10000; IP: 1:10 - 1:100; FC: 1:100 - 1:500; ICC/IF: 1:50 - 1:100
BufferpH: 7.20; Preservative: 0.01% Sodium azide; Constituents: 49% PBS, 50% Glycerol, 0.05% BSA
Note Is unsuitable for IHC-P.

Reference Data

Target NameHomo sapiens histone cell cycle regulator (HIRA)
Alternative NameDGCR1; TUP1; TUPLE1
Database LinkNP_003316
Entrez Gene 7290 Human
FunctionHIRA is a histone chaperone that preferentially places the variant histone H3.3 in nucleosomes. Orthologs of this protein in yeast, flies, and plants are necessary for the formation of transcriptionally silent heterochromatin. HIRA plays an important role in the formation of the senescence-associated heterochromatin foci. These foci likely mediate the irreversible cell cycle changes that occur in senescent cells. It is considered the primary candidate protein in some haploinsufficiency syndromes such as DiGeorge syndrome, and insufficient production of HIRA may disrupt normal embryonic development (1).
Related PathwayTranscription Factors

* Availability is in business days
* OriGene provides validated application data and protocol, with money back guarantee.

Western blot - Anti-HIRA antibody [EPR7416]; All lanes : Anti-HIRA antibody [EPR7416] at 1/1000 dilution.Lane 1 : 293T cell lysates.Lane 2 : HeLa cell lysates.Lane 3 : K562 cell lysates.Lysates/proteins at 10 ug per lane.Secondary.HRP labelled Goat anti-Rabbit IgG at 1/2000 dilution.Predicted band size : 112 kDa.
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Other-Anti-HIRA antibody [EPR7416](TA310575); Equilibrium disassociation constant (KD)..
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Immunocytochemistry/ Immunofluorescence - Anti-HIRA antibody [EPR7416]; TA310575, at 1/50 dilution, staining HIRA in HeLa cells by Immunofluorescence.
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