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Home Antibody All anti-HDAC1 antibodies

Anti-HDAC1 Antibody EPR460(2)

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Specifications Citations Related Products Product Documents
SKU Description Amount Price Availability*  
TA307790
  • Rabbit monoclonal antibody against Histone Deacetylase 1(clone EPR460(2))
  • Free Sample of Positive Control: HEK293T cell transient overexpression lysate (LC417624) , 20ug Explanation
100ul 325 In Stock
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WB(1)
IHC(2)
IF(1)
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Also for HDAC1 (NM_004964)
cDNA Clone shRNA/siRNA Lysate Protein Antibody

OriGene Data

ImmunogenA synthetic peptide corresponding to residues near the C-terminus of human Histone Deacetylase 1 was used as an immunogen.
Clone NameEPR460(2) IsotypeIgG
Species ReactivityMouse, Rat, Human ConcentrationLot dependent; please refer to CoA along with shipment
Guaranteed Application *WB, IHC, IF Suggested DilutionsICC/IF: 1:400; WB: 1:1000 - 1:10000; IHC-P: 1:50 - 1:100; ICC: 1:250 - 1:500
Predicted MW Explanation 55 kDa
BufferPBS 49%,Sodium azide 0.01%,Glycerol 50%,BSA 0.05%
Purification Tissue culture supernatant
Note Is unsuitable for Flow Cyt or IP.

Reference Data

Target NameHomo sapiens histone deacetylase 1 (HDAC1)
Alternative NameGON-10; HD1; RPD3; RPD3L1
Database LinkNP_004955
Entrez Gene 3065 Human
Entrez Gene 433759 Mouse
Entrez Gene 297893 Rat
FunctionHistone Deacetylase 1 belongs to the histone deacetylase/acuc/apha family and is a component of the histone deacetylase complex. Histone acetylation and deacetylation, catalyzed by multisubunit complexes, play a key role in the regulation of eukaryotic gene expression. It also interacts with retinoblastoma tumor-suppressor protein and this complex is a key element in the control of cell proliferation and differentiation. Together with metastasis-associated protein-2, it deacetylates p53 and modulates its effect on cell growth and apoptosis (1).
Related PathwayStem cell relevant signaling - DSL/Notch pathwayStem cell - PluripotencyAdult stem cellsTranscription FactorsDruggable Genome Cell cycleNotch signaling pathwayHuntington's diseasePathways in cancerChronic myeloid leukemia

* Availability is in business days
* OriGene provides validated application data and protocol, with money back guarantee.

WB Image
Western blot - HDAC1 antibody [EPR460(2)]; All lanes : Anti-HDAC1 antibody [EPR460(2)] at 1/1000 dilution.Lane 1 : Jurkat cell lysate.Lane 2 : HeLa cell lysate.Lane 3 : K562 cell lysate.Lane 4 : MCF7 cell lysate.Lysates/proteins at 10 ug per lane.Predicted band size : 55 kDa.
IHC Image
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - HDAC1 antibody [EPR460(2)]; Immunohistochemical analysis of HDAC1 in paraffin-embedded Human colon tissue using TA307790 at 1/50 dilution.
IHC Image
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - HDAC1 antibody [EPR460(2)]; Immunohistochemical analysis of HDAC1 in paraffin-embedded Human tonsil tissue using TA307790 at 1/50 dilution.
IF Image
Immunocytochemistry/ Immunofluorescence - Anti-HDAC1 antibody [EPR460(2)]; TA307790 (1/400) staining HDAC1 in HeLa cells (green). Cells were fixed in paraformaldehyde, permeabilised in 0.5% Triton X100/PBS and counterstained with DAPI in order to highlight the nucleus (red).

 

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