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Home Antibody All anti-HAVCR2 antibodies

Anti-HAVCR2 Antibody RMT3-23


Specifications Citations Customer Reviews Product Documents
SKU Description Amount Price Availability*  
TA320344 Rat Anti-Mouse TIM3 Purified (50 ug) 50ug $120 3-7 Days
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OriGene Data

Clone NameRMT3-23 Isotype
Species ReactivityMouse Concentration0.5-1mg/ml (lot dependent)
Guaranteed Application * Suggested DilutionsFlow
BufferAqueous buffer, 0.09% sodium azide, may contain carrier protein/stabilizer
Purification Affinity purified

Reference Data

Target NameMus musculus hepatitis A virus cellular receptor 2 (Havcr2)
Alternative NameTIM-3; Tim3; Timd3
Database LinkNP_599011
Entrez Gene 171285 Mouse
FunctionThe RMT3-23 monoclonal antibody reacts with mouse Tim-3, a Th1-specific cell surface protein. The RMT3-23 antibody reacts with Tim-3 protein expressed by both BALB/c and C57BL/6 strains of mice. Tim-3, a type I transmembrane protein, contains an immunoglobulin and a mucin-like domain in its extracellular portion and a tyrosine phosphorylation motif in its cytoplasmic portion. Tim-3 is expressed selectively by differentiated CD4+Th1 and CD8+Tc1 cells, but is absent on CD4+Th2 and CD8+Tc2 cells. Other hematopoietic cell types, including na?ve T cells, B cells, macrophages and dendritic cells, do not express Tim-3, at least at the protein level. Tim-3 expression is upregulated at a late stage of T cell differentiation on Th1 cells after 3 rounds of in vitro polarization suggesting a role for this molecule in the transport or effector function of Th1 cells rather than a contribution to T cell differentiation. In an experimental autoimmune encephalomyelitis (EAE) model, Tim-3 was shown to be expressed on most CD4+ and CD8+ T cells in the central nervous system at the onset of clinical signs of disease, while less than 2% of CD4+ cells in the periphery expressed Tim-3 after immunization.RMT3-23 has been shown to have functional activity; blocks DC recognition of apoptotic cells and also induces autoantibody production.
Related Pathway

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