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Home Antibody All anti-HAP1 antibodies

Anti-HAP1 Antibody

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Specifications Citations Related Products Product Documents
SKU Description Amount Price Availability*  
TA306425
  • Rabbit Polyclonal HAP1 Antibody
100ug 325 In Stock
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WB(1)
IHC(1)

OriGene Data

ImmunogenHAP1 antibody was raised against a 19 amino acid peptide from near the center of human HAP1.
Clone Name IsotypeIgG
Species ReactivityHuman, Mouse, Rat ConcentrationLot dependent; please refer to CoA along with shipment
Guaranteed Application *WB, IHC Suggested DilutionsWB: 0.5 - 1 ug/ml
BufferPBS containing 0.02% sodium azide.
Purification Affinity chromatography purified via peptide column

Reference Data

Target NameHomo sapiens huntingtin-associated protein 1 (HAP1), transcript variant 3
Alternative NameHAP2; hHLP1; HIP5; HLP
Database LinkNP_001073339
Entrez Gene 9001 Human
Entrez Gene 15114 Mouse
Entrez Gene 29430 Rat
FunctionHuntington's disease (HD), a neurodegenerative disorder characterized by loss of striatal neurons, is caused by an expansion of a polyglutamine tract in the HD protein huntingtin. HAP1 was initially identified through a two-hybrid library screening; the binding of HAP1 to huntingtin correlated with the expansion of the polyglutamine tract. HAP1 also interacts with two cytoskeletal proteins (dynactin and pericentriolar autoantigen protein 1), suggesting that HAP1 may play a role in vesicular trafficking or organelle transport. HAP1 is also involved with the huntingtin-enhanced BDNF transport along the cellular microtubles. Attenuation of this process led to the loss of neurotrophic support and neuronal toxicity, which suggests that loss of this function might contribute to pathogenesis. Several alternatively spliced isoforms have been described for HAP1.
Related Pathway

* Availability is in business days
* OriGene provides validated application data and protocol, with money back guarantee.

WB Image
Western blot analysis of HAP1 in mouse brain tissue lysate with HAP1 antibody at (A) 0.5 and (B) 1 ug/ml.
IHC Image
Immunohistochemistry of HAP1 in human brain tissue with HAP1 antibody at 2.5 ug/ml.

 

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