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Also for H2AFZ (NM_002106)
|Synthetic peptide corresponding to a region within amino acids 1 and 45 of Histone H2A.Z|
|Human (Predicted: Mouse, Rat, Zebrafish, Xenopus laevis, Xenopus Tropicalis, Pig, Chicken, Sheep, Rhesus Monkey, Bovine)
|WB, IHC, IF
||ICC/IF:1:100-1:1000; IHC:1:100-1:1000; WB:1:500-1:3000
|0.1M Tris, 0.1M Glycine, 10% Glycerol (pH7). 0.01% Thimerosal was added as a preservative.|
|Purified by antigen-affinity chromatography.
|Seq homology of immunogen across species: Mouse (100%), Rat (100%), Zebrafish (100%), Xenopus laevis (92%), Xenopus Tropicalis (92%), Pig (100%), Chicken (93%), Sheep (100%), Rhesus Monkey (100%), Bovine (100%)
|Homo sapiens H2A histone family, member Z (H2AFZ)|
|H2A.z; H2A.Z-1; H2A/z; H2AZ|
Entrez Gene 3015 Human
Entrez Gene 51788 Mouse
Entrez Gene 58940 Rat
Entrez Gene 709326 Monkey
|Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Nucleosomes consist of approximately 146 bp of DNA wrapped around a histone octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further compacted through the interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin structures. This gene encodes a replication-independent member of the histone H2A family that is distinct from other members of the family. Studies in mice have shown that this particular histone is required for embryonic development and indicate that lack of functional histone H2A leads to embryonic lethality. [provided by RefSeq]|
|Druggable Genome Systemic lupus erythematosus|
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Sample (30 ug of whole cell lysate). A: JurKat. 15% SDS PAGE. TA308894 diluted at 1:1000.
Immunohistochemical analysis of paraffin-embedded SCC4 xenograft, using Histone H2A.Z(TA308894) antibody at 1:100 dilution.
Confocal immunofluorescence analysis (Olympus FV10i) of paraformaldehyde-fixed A431, using Histone H2A.Z(TA308894) antibody (Green) at 1:500 dilution. Alpha-tubulin filaments were labeled with anti-alpha tubulin antibody (Red) at 1:500.