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Anti-Gfra3 Antibody


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SKU Description Amount Price Availability*  
  • Rabbit Polyclonal GFR alpha 3 Antibody
  • Free Sample of Positive Control: HEK293T cell transient overexpression lysate (LC400574) , 20ug Explanation
100ug 325 3-7 Days
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OriGene Data

ImmunogenGFR alpha 3 antibody was raised against a peptide corresponding to amino acids from 347 to 360 of murine GFR alpha 3.
Clone Name IsotypeIgG
Species ReactivityHuman, Mouse, Rat Concentration1ug/ul
Guaranteed Application *WB, IHC Suggested DilutionsWB: 1:500 - 1:1000
BufferPBS containing 0.02% sodium azide.
Purification Antibody is DEAE purified

Reference Data

Target NameHomo sapiens GDNF family receptor alpha 3 (GFRA3)
Alternative NameGDNFR3
Database LinkNP_001487
Entrez Gene 2676 Human
Entrez Gene 14587 Mouse
Entrez Gene 84422 Rat
FunctionMembers of the glial cell line-derived neurotrophic factor (GDNF) family including GDNF and neurturin (NTN) play essential roles in the control of vertebrate neuron survival and differentiation. A new member of the GDNF family was recently identified and designated persephin. Physiological responses to these neurotrophic factors require two receptor subunits, the novel glycosylphosphadidylinositol linked protein GFRalpha and Ret receptor tyrosine kinase GFRbeta (2). Following the findings of GFRΑ-1 and -2, a novel receptor in GFRalpha family was identified very recently from human and mouse and designated GFRalpha-3. GFRalpha-3 binds persephin, thus, persephin, GFRalpha-3, and Ret PTK form a complex to transduce persephin signal and to mediate persephin function.
Related PathwayDruggable Genome

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WB Image
Western blot analysis of GFR alpha 3 in crude cell membrane fractions of mouse heart (H), spleen (S), kidney (K), liver (L), and brain (B), respectively, with GFR alpha 3 antibody at 1:500 dilution.
IHC Image
Immunohistochemistry of GFRa-3 in mouse heart tissue with GFRa-3 antibody at 10 ug/ml.


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