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Home Antibody All anti-Gabbr2 antibodies

Anti-Gabbr2 Antibody S81-2

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Specifications Citations (0) Related Products Product Documents
SKU Description Amount Price Availability*  
TA326531 Mouse Monoclonal Anti-GABA-B Receptor 2 Antibody 100µg $325 3-7 Days

Buy any antibody of 100ul or more, get a free package of 3 loading control antibody samples. View Details Add to Shopping Cart

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OriGene Data

ImmunogenFusion protein amino acids 861-912 of rat GABA(B)R2
Clone NameS81-2 IsotypeIgG1
Species ReactivityHuman, Mouse, Rat Concentration1mg/mL
Guaranteed Application * Suggested Dilutions
BufferPBS pH7.4, 50% glycerol
Purification Protein G Purified
Note Detects ~105kDa. No cross-reactivity against GABA(B)R1

Reference Data

Target NameRattus norvegicus gamma-aminobutyric acid (GABA) B receptor 2 (Gabbr2)
Alternative NameGpr51
Database LinkNP_113990
Entrez Gene 9568 Human
Entrez Gene 242425 Mouse
Entrez Gene 83633 Rat
FunctionGABA (-aminobutyric acid) is the primary inhibitory neurotransmitter in the central nervous system and interacts with three different receptors: GABA(A), GABA(B) and GABA(C) receptor. The ionotropic GABA(A) and GABA(C) receptors are ligand-gated ion channels that produce fast inhibitory synaptic transmission. In contrast, the metabotropic GABA(B) receptor is coupled to G proteins that modulate slow inhibitory synaptic transmission . Functional GABA(B) receptors form heterodimers of GABA(B)R1 and GABA(B)R2 where GABA(B)R1 binds the ligand and GABA(B)R2 is the primary G protein contact site . Two isoforms of GABA(B)R1 have been cloned: GABA(B)R1a is a 130 kD protein and GABA(B)R1b is a 95 kD protein . G proteins subsequently inhibit adenyl cylase activity and modulate inositol phospholipid hydrolysis. GABA(B) receptors have both pre- and postsynaptic inhibitions: presynaptic GABA(B) receptors inhibit neurotransmitter release through suppression of high threshold calcium channels, while postsynaptic GABA(B) receptors inhibit through coupled activation of inwardly rectifying potassium channels. In addition to synaptic inhibition,GABA(B) receptors may also be involved in hippocampal long-term potentiation, slow wave sleep and muscle relaxation .
Related Pathway

* Availability is in business days
* OriGene provides validated application data and protocol, with money back guarantee.

 

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