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Home Antibody All anti-Gabbr1 antibodies

Anti-Gabbr1 Antibody S93A-49

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Specifications Citations Related Products Product Documents
SKU Description Amount Price Availability*  
TA326530
  • Mouse Monoclonal Anti-GABA-B Receptor 1 Antibody
100µg 325 3-7 Days
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WB(1)

OriGene Data

ImmunogenFusion protein amino acids 873-977 (cytoplasmic C-terminus) of rat GABA(B)R1
Clone NameS93A-49 IsotypeIgG1
Species ReactivityHuman, Mouse, Rat Concentration1mg/mL
Guaranteed Application *WB Suggested Dilutions
BufferPBS pH7.4, 50% glycerol
Purification Protein G Purified
Note Detects ~115kDa. No cross-reactivity against GABA(B)R2

Reference Data

Target NameRattus norvegicus gamma-aminobutyric acid (GABA) B receptor 1 (Gabbr1)
Alternative Name
Database LinkNP_112290
Entrez Gene 2550 Human
Entrez Gene 54393 Mouse
Entrez Gene 81657 Rat
FunctionGABA (-aminobutyric acid) is the primary inhibitory neurotransmitter in the central nervous system andinteracts with three different receptors: GABA(A), GABA(B) and GABA(C) receptor. The ionotropic GABA(A) and GABA(C) receptors are ligand-gated ion channels that produce fast inhibitory synaptic transmission. In contrast, the metabotropic GABA(B) receptor is coupled to G proteins that modulate slow inhibitory synaptic transmission . Functional GABA(B) receptors form heterodimers of GABA(B)R1 and GABA(B)R2 where GABA(B)R1 binds the ligand and GABA(B)R2 is the primary G protein contact site . Two isoforms of GABA(B)R1 have been cloned: GABA(B)R1a is a 130 kD protein and GABA(B)R1b is a 95 kD protein . G proteins subsequently inhibit adenyl cylase activity and modulate inositol phospholipid hydrolysis. GABA(B) receptors have both pre- and postsynaptic inhibitions: presynaptic GABA(B) receptors inhibit neurotransmitter release through suppression of high threshold calcium channels, while postsynaptic GABA(B) receptors inhibitthrough coupled activation of inwardly rectifying potassium channels. In addition to synaptic inhibition, GABA(B) receptors may also be involved in hippocampal long-term potentiation, slow wave sleep and muscle relaxation .
Related Pathway

* Availability is in business days
* OriGene provides validated application data and protocol, with money back guarantee.

WB Image
Western blot analysis of GABA(Beta)R1 in rat brain membrane tissues, using a 1:1000 dilution of the antibody

 

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