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Also for GSTA2 (NM_000846)
|Recombinant fragment corresponding to a region within amino acids 1 and 196 of GSTA2 (Uniprot ID#P09210)|
|Human (Predicted: Monkey, Pig)
|WB, IHC, IF
||ICC/IF:1:100-1:1000; IHC:1:100-1:1000; WB:1:500-1:3000
|0.1M Tris, 0.1M Glycine, 10% Glycerol (pH7). 0.01% Thimerosal was added as a preservative.|
|Purified by antigen-affinity chromatography.
|Seq homology of immunogen across species: Monkey (92%), Pig (82%)
|Homo sapiens glutathione S-transferase alpha 2 (GSTA2)|
|GST2; GSTA2-2; GTA2; GTH2|
Entrez Gene 2939 Human
Entrez Gene 709037 Monkey
|Cytosolic and membrane-bound forms of glutathione S-transferase are encoded by two distinct supergene families. These enzymes function in the detoxification of electrophilic compounds, including carcinogens, therapeutic drugs, environmental toxins and products of oxidative stress, by conjugation with glutathione. The genes encoding these enzymes are known to be highly polymorphic. These genetic variations can change an individual's susceptibility to carcinogens and toxins as well as affect the toxicity and efficacy of some drugs. At present, eight distinct classes of the soluble cytoplasmic mammalian glutathione S-transferases have been identified: alpha, kappa, mu, omega, pi, sigma, theta and zeta. This gene encodes a glutathione S-tranferase belonging to the alpha class. The alpha class genes, located in a cluster mapped to chromosome 6, are the most abundantly expressed glutathione S-transferases in liver. In addition to metabolizing bilirubin and certain anti-cancer drugs in the liver, the alpha class of these enzymes exhibit glutathione peroxidase activity thereby protecting the cells from reactive oxygen species and the products of peroxidation. [provided by RefSeq]|
| Glutathione metabolismMetabolism of xenobiotics by cytochrome P450Drug metabolism - cytochrome P450|
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Sample(30 ug of whole cell lysate). A:Hep G2. 12% SDS PAGE. TA308025 diluted at 1:3000
Immunohistochemical analysis of paraffin-embedded Stomach, using GSTA2(TA308025) antibody at 1:100 dilution.
Immunofluorescence analysis of methanol-fixed Hep G2, using GSTA2(TA308025) antibody at 1:500 dilution.