Glutathione Reductase is a member of the class-I pyridine nucleotide-disulfide oxidoreductase family. This enzyme is a homodimeric flavoprotein. Glutathione Reductase is a central enzyme of cellular antioxidant defense and reduces oxidized glutathione disulfide (GSSG) to the sulfhydryl form GSH, which is an important cellular antioxidant. Rare mutations in Glutathione Reductase result in hereditary glutathione reductase deficiency (1).
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