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Home Antibody All anti-GSK3B antibodies

Anti-GSK3B Antibody N/A

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Specifications Citations Related Products Product Documents
SKU Description Amount Price Availability*  
TA326426
  • Rabbit polyclonal GSK-3Beta Antibody
  • Free Sample of Positive Control: HEK293T cell transient overexpression lysate (LC419542) , 20ug Explanation
100µg 325 3-7 Days
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WB(1)
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Also for GSK3B (NM_002093)
cDNA Clone shRNA/siRNA Lysate Protein Antibody

OriGene Data

ImmunogenSynthetic peptide corresponding to the sequence near the C-terminus of human GSK-3Beta.
Clone NameN/A IsotypeN/A
Species ReactivityHuman, Mouse, Rat, Bovine Concentration1.3mg/mL
Guaranteed Application *WB Suggested DilutionsWB: 1:2000
BufferPBS pH7.4
Purification Affinity Purified
Note Detects ~47kDa.

Reference Data

Target NameHomo sapiens glycogen synthase kinase 3 beta (GSK3B), transcript variant 1
Alternative NameGSK3beta isoform; glycogen synthase kinase-3 beta; glycogen synthase kinase 3 beta
Database LinkNP_002084
Entrez Gene 2932 Human
Entrez Gene 56637 Mouse
Entrez Gene 84027 Rat
FunctionGlycogen synthase kinase 3, is a serine/threonine protein kinase that mediates the addition of phosphate molecules onto serine and threonine amino acid residues. It has also been shown to regulate immune and migratory processes, and is tied to pathways of cell proliferation and apoptosis .In mammals, it is encoded by two genes- GSK-3Alpha and GSK-3Beta. They are structurally similar, but functionally non-identical. GSK-3Alpha is inhibited by phosphorylation at S21 by Akt and other kinases. GSK-3Beta negatively regulates cardiac hypertrophy and cardiac development through its effect on WNT signaling . GSK-3 alpha and GSK-3 beta share 85% amino acid identity. GSK-3 has been implicated in a number of diseases including Type II diabetes, Alzheimers, cancer and bipolar .
Related Pathway
Cell cycle
Delta-Notch Signaling Pathway
Focal Adhesion
Hedgehog signaling pathway
Melanogenesis
Senescence and Autophagy
Wnt Signaling Pathway

* Availability is in business days
* OriGene provides validated application data and protocol, with money back guarantee.

WB Image
Western blot analysis of GSK-3Beta in a cell line mix, using a 1:1000 dilution of the antibody

 

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