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Home Antibody All anti-GSK3A antibodies

Anti-GSK3A Antibody EP933Y

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Specifications Citations Related Products Product Documents
SKU Description Amount Price Availability*  
TA301066
  • Rabbit Monoclonal Antibody against GSK3A (Clone EP933Y)
  • Free Sample of Positive Control: HEK293T cell transient overexpression lysate (LC412674) , 20ug Explanation
100ul 325 3-7 Days
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WB(1)
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Also for GSK3A (NM_019884)
cDNA Clone shRNA/siRNA Lysate Protein Antibody

OriGene Data

ImmunogenA synthetic peptide corresponding to residues in human GSK3?/? was used as an immunogen. This antibody detects both GSK ? and GSK3?.
Clone NameEP933Y IsotypeIgG
Species ReactivityMouse, Rat, Human ConcentrationLot dependent; please refer to CoA along with shipment
Guaranteed Application *WB Suggested DilutionsWB: 1: 1000~2000
Predicted MW Explanation 51 kDa
BufferPBS 49%,Sodium azide 0.01%,Glycerol 50%,BSA 0.05%
Purification Tissue culture supernatant

Reference Data

Target NameHomo sapiens glycogen synthase kinase 3 alpha (GSK3A)
Alternative NameDKFZp686D0638
Database LinkNP_063937
Entrez Gene 2931 Human
Entrez Gene 606496 Mouse
Entrez Gene 50686 Rat
FunctionGlycogen synthases kinase 3 alpha (GSK3-?) is a multifunctional Serine/Threonine protein kinase, one of two isoforms of GSK3 (1). Originally identified as a regulator of glycogen synthase, it has been shown to be involved in the hormonal control of several regulatory factors and transcription factors. GSK3-? activity is down regulated by phosphorylation on Serine 21 by PKB, or activated by phosphorylation on Tyrosine 279 (2). Insulin inactivates GSK3-? by rapid phosphorylation which leads to activation of Glycogen Synthase in the cells (3). GSK3-? activitiy has been linked to a pathogenic mechanism in Alzheimer's disease (4). GSK3 beta) plays a key role in insulin and Wnt signaling, phosphorylating downstream targets by default, and becoming inhibited following the extracellular signaling event (5).
Related PathwayProtein KinaseDruggable Genome Chemokine signaling pathway

* Availability is in business days
* OriGene provides validated application data and protocol, with money back guarantee.

WB Image
Western blot - GSK3 (alpha + beta) antibody [EP933Y]; Anti-GSK3 (alpha + beta) antibody [EP933Y] at 1/2000 dilution + 293T cell lysate at 10 ug.Secondary.goat anti-rabbit, HRP labeled, at 1/2000 dilution.Predicted band size : 51,47 kDa.

 

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