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Anti-GSK3A Antibody EP933Y
Also for GSK3A (NM_019884)
|A synthetic peptide corresponding to residues in human GSK3?/? was used as an immunogen. This antibody detects both GSK ? and GSK3?.|
|Human, Mouse, Rat
||0.5~1.0 mg/ml (Lot Dependent)
||WB: 1: 1000~2000
|PBS 49%,Sodium azide 0.01%,Glycerol 50%,BSA 0.05%|
|Tissue culture supernatant (Protein A or G Sepharose)
|Homo sapiens glycogen synthase kinase 3 alpha (GSK3A)|
|Glycogen synthases kinase 3 alpha (GSK3-?) is a multifunctional Serine/Threonine protein kinase, one of two isoforms of GSK3 (1). Originally identified as a regulator of glycogen synthase, it has been shown to be involved in the hormonal control of several regulatory factors and transcription factors. GSK3-? activity is down regulated by phosphorylation on Serine 21 by PKB, or activated by phosphorylation on Tyrosine 279 (2). Insulin inactivates GSK3-? by rapid phosphorylation which leads to activation of Glycogen Synthase in the cells (3). GSK3-? activitiy has been linked to a pathogenic mechanism in Alzheimer's disease (4). GSK3 beta) plays a key role in insulin and Wnt signaling, phosphorylating downstream targets by default, and becoming inhibited following the extracellular signaling event (5). |
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Western blot - GSK3 (alpha + beta) antibody [EP933Y]; Anti-GSK3 (alpha + beta) antibody [EP933Y] at 1/2000 dilution + 293T cell lysate at 10 µg.Secondary.goat anti-rabbit, HRP labeled, at 1/2000 dilution.Predicted band size : 51,47 kDa.