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Home Antibody All anti-GRM1 antibodies
UltraMAB

Anti-GRM1 GAT Antibody Polyclonal

Generated by Genomic Immunization

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Specifications Citations Related Products Product Documents
SKU Description Amount Price Availability*  
TA590051
  • Rabbit Polyclonal metabotropic Glutamate Receptor 1 Antibody
50ug 325 In Stock
This antibody qualifies for Season of Giving promotion: Earn $50 Amazon gift card (use promo code SPQ12081) or donation to Cancer.org (promo code SPQ12082) with $600 purchase of UltraMAB or TrueMAB. Click for details
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ELISA(1)

OriGene Data

ImmunogenDNA immunization. This antibody is specific for the C Terminus Region mGluR1.
Clone NamePolyclonal IsotypeIgG
Species ReactivityHuman Concentration1.11mg/ml
Guaranteed Application *ELISA Suggested DilutionsWB: 1:5000-1:20000; ELISA: 1:100-1:2000
Predicted MW Explanation 132 kDa
Buffer20 mM Potassium Phosphate, 150 mM Sodium Chloride, pH 7.0
Purification The fragment used for DNA immunization was expressed in E.coli and the purified protein fragment was used for affinity purification of the antibody.
Note This antibody was generated by SDIX's Genomic Antibody Technology ® (GAT). Learn about GAT

Reference Data

Target NameHomo sapiens glutamate receptor, metabotropic 1 (GRM1), transcript variant 1
Alternative NameGPRC1A; GRM1A; mGlu1; MGLUR1; MGLUR1A; SCAR13
Database LinkNP_000829
Entrez Gene 2911 Human
FunctionThe Metabotropic Glutamate Receptor mGluR1 binds L-glutamate, the major excitatory neurotransmitter in the central nervous system, which activates both ionotropic and metabotropic glutamate receptors. Glutamatergic neurotransmission is involved in most aspects of normal brain function and can be perturbed in many neuropathologic conditions. mGluR1 and mGluR5 are group I receptors that have been shown to activate phospholipase C. Alternative splice variants of the mGluR1 gene have been described, but their full-length nature has not been determined. Inflammation results in the activation of mGluR1 and mGluR5 in dorsal horn neurons of the spinal cord, leading to extracellular signal-regulated kinase (ERK) activation, which is required for nociceptive plasticity and enhanced pain. mGluR1 has been reported in various regions of the brain and spinal cord. ESTs have been isolated from brain and eye libraries. Caution: GLUR1 refers to Ionotropic Glutamate Receptor 1, not to Metabotropic Glutamate Receptor 1 (mGLUR1).
Related PathwayGPCRTransmembraneDruggable Genome Calcium signaling pathwayNeuroactive ligand-receptor interactionGap junctionLong-term potentiationLong-term depression

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ELISA Image
ELISA: mGluR1 Antibody - Metabotropic Glutamate Receptor 1 Antibody

 

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