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Home Antibody All anti-GRIK4 antibodies

Anti-GRIK4 Antibody

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Specifications Citations Related Products Product Documents
SKU Description Amount Price Availability*  
TA306499
  • Rabbit Polyclonal Grik4 Antibody
  • FREE positive control: HEK293T cell transient overexpression lysate (LC415171) , 20ug
100ug $325 In Stock
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WB(1)
IHC(1)

OriGene Data

ImmunogenGrik4 antibody was raised against a 14 amino acid peptide near the amino terminus of the human Grik4.
Clone Name IsotypeIgG
Species ReactivityHuman, Mouse, Rat Concentration1mg/ml
Guaranteed Application *WB, IHC Suggested DilutionsWB: 0.5 - 1 ug/ml
BufferPBS containing 0.02% sodium azide.
Purification Affinity chromatography purified via peptide column

Reference Data

Target NameHomo sapiens glutamate receptor, ionotropic, kainate 4 (GRIK4), transcript variant 2
Alternative NameEAA1; GluK4; GRIK; KA1
Database LinkNP_055434
FunctionGrik4 codes for the KA1 subunit of kainate-type ionotropic glutamate receptors which are critical regulators of network activity that act by modifying neuronal excitability, directly and indirectly, through GABAergic interneurons. Five subunits can assemble to form kainate receptors (KARs): GluR5 (coded by Grik1), GluR6 (coded by Grik2), and GluR7 (coded by Grik3) are the low-affinity subunits, and KA1 and KA2 are the high-affinity subunits. In the adult brain, KARs are located pre- and postsynaptically on pyramidal cells and on interneurons. Kainate receptors on GABA-containing interneurons enhance GABA release and thereby downregulate glutamatergic signaling. KARs have been implicated in numerous psychiatric disorders. Case control studies show significant association of Grik4 with both schizophrenia and bipolar disorder. Despite its predicted molecular weight, Grik4 often migrates at a lower molecular weight in SDS-PAGE.
Related Pathway

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WB Image
Western blot analysis of Grik4 in Rat brain tissue lysate with Grik4 antibody at (A) 0.5, (B) 1 and (C) 2 ug/ml.
IHC Image
Immunohistochemical staining of human brain tissue using Grik4 antibody at 2.5 ug/ml.

 

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