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Home Antibody All anti-GRIK3 antibodies

Anti-GRIK3 Antibody

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Specifications Citations Related Products Product Documents
SKU Description Amount Price Availability*  
TA306497
  • Rabbit Polyclonal Grik3 Antibody
  • Free Sample of Positive Control: HEK293T cell transient overexpression lysate (LC424496) , 20ug Explanation
100ug 325 3-7 Days
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WB(1)

OriGene Data

ImmunogenGrik3 antibody was raised against a 13 amino acid peptide near the amino terminus of the human Grik3.
Clone Name IsotypeIgG
Species ReactivityHuman, Mouse, Rat Concentration1ug/ul
Guaranteed Application *WB Suggested DilutionsWB: 1 - 2 ug/ml
BufferPBS containing 0.02% sodium azide.
Purification Affinity chromatography purified via peptide column

Reference Data

Target NameHomo sapiens glutamate receptor, ionotropic, kainate 3 (GRIK3)
Alternative NameEAA5; GLR7; GluK3; GLUR7; GluR7a
Database LinkNP_000822
Entrez Gene 2899 Human
Entrez Gene 14807 Mouse
Entrez Gene 298521 Rat
FunctionGlutamate receptors are the predominant excitatory neurotransmitter receptors in the mammalian brain and are activated in a variety of normal neurophysiologic processes. Grik3, also known as glutamate receptor 7, belongs to the kainate family of glutamate receptors, which are composed of four subunits and function as ligand-activated ion channels. Grik3 is highly homologous to the related ionotrophic glutamate receptors Grik2 and Grik1. Grik3 has recently been shown to be an essential subunit of presynaptic kainate autoreceptors at hippocampal mossy fiber synapses as grik3-null mice show significantly reduced short- and long-term synaptic potentiation. Other reports have suggested that different polymorphisms in the Grik3 protein may be associated with neurological defects such as recurrent major depressive disorder and schizophrenia. This Grik3 antibody does not cross-react with Grik2.
Related PathwayTransmembraneIon Channels: Glutamate ReceptorsDruggable Genome Neuroactive ligand-receptor interaction

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WB Image
Western blot analysis of Grik3 in human brain tissue lysate with Grik3 antibody at (A) 1 and (B) 2 µg/ml.

 

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