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Home Antibody All anti-GRIA2 antibodies

Anti-GRIA2 PHOSPHO Antibody EP929Y

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Specifications Citations Related Products Product Documents
SKU Description Amount Price Availability*  
TA303528
  • Rabbit monoclonal antibody against GluR2/3 (EP929Y ) (phospho-specific)
100ul 325 3-7 Days
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WB(1)
IHC(1)

OriGene Data

ImmunogenA synthetic phospho-peptide corresponding to residues surrounding Ser880/891 of human GluR2/3 was used as immunogen. The antibody detects both GluR2/3 phosphorylated on Serine 880/891 of the mature human, and also unphosphorylated Glur-2/3.
Clone NameEP929Y IsotypeIgG
Species ReactivityMouse, Rat, Human ConcentrationLot dependent; please refer to CoA along with shipment
Guaranteed Application *WB, IHC Suggested DilutionsWB: 1:5000; IP: 1:100; IHC-P: Use at an assay dependent dilution; ICC/IF: 1:100 - 1:250
BufferPBS 49%,Sodium azide 0.01%,Glycerol 50%,BSA 0.05%
Purification Tissue culture supernatant
Note Is unsuitable for Flow Cyt.

Reference Data

Target NameHomo sapiens glutamate receptor, ionotropic, AMPA 2 (GRIA2), transcript variant 1
Alternative NameGluA2; GluR-K2; GLUR2; GLURB; HBGR2
Database LinkNP_000817
FunctionGlutamate receptors are the predominant excitatory neurotransmitter receptors in the mammalian brain and are activated in a variety of normal neurophysiologic processes. This gene product belongs to a family of glutamate receptors that are sensitive to alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate (AMPA), and function as ligand-activated cation channels. These channels are assembled from 4 related subunits, GRIA1-4. The subunit encoded by this gene (GRIA2) is subject to RNA editing (CAG->CGG; Q->R) within the second transmembrane domain, which is thought to render the channel impermeable to Ca(2+). Human and animal studies suggest that pre-mRNA editing is essential for brain function, and defective GRIA2 RNA editing at the Q/R site may be relevant to amyotrophic lateral sclerosis (ALS) etiology. Alternative splicing, resulting in transcript variants encoding different isoforms, (including the flip and flop isoforms that vary in their signal transduction properties), has been noted for this gene. [provided by RefSeq].
Related Pathway

* Availability is in business days
* OriGene provides validated application data and protocol, with money back guarantee.

WB Image
Western blot - GluR2 + 3 antibody [EP929Y]; Anti-Ionotropic glutamate receptor 2 + 3 antibody [EP929Y] at 1/5000 dilution + human brain lysate at 10 ug.Secondary.goat anti-rabbit HRP at 1/2000 dilution.Predicted band size : 98 kDa.Observed band size : 98 kDa.
IHC Image
Immunohistochemistry (Paraffin-embedded sections) - GluR2 + 3 antibody [EP929Y]; TA303528 at 1/100 dilution staining GluR2 +3 in human brain by Immunohistochemsitry, Paraffin embedded tissue.

 

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