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Home Antibody All anti-GRIA2 antibodies

Anti-GRIA2 Antibody EP966Y

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Specifications Citations Related Products Product Documents
SKU Description Amount Price Availability*  
TA303527
  • Rabbit monoclonal antibody against GluR-2(EP966Y)
100ul 325 3-7 Days
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WB(2)

OriGene Data

ImmunogenA synthetic peptide corresponding to a residue near N-term of human Glutamate receptor type 2 was used as immunogen.
Clone NameEP966Y IsotypeIgG
Species ReactivityHuman, Mouse, Rat Concentration0.5~1.0 mg/ml (Lot Dependent)
Guaranteed Application *WB Suggested DilutionsWB: 1:2000; IP: 1:40; FC: 1:30
BufferPBS 49%,Sodium azide 0.01%,Glycerol 50%,BSA 0.05%
Purification Tissue culture supernatant
Note Is unsuitable for ICC/IF,IHC-Fr or IHC-P.

Reference Data

Target NameHomo sapiens glutamate receptor, ionotropic, AMPA 2 (GRIA2), transcript variant 1
Alternative NameGluA2; GluR-K2; GLUR2; GLURB; HBGR2
Database LinkNP_000817
FunctionGlutamate receptors are the predominant excitatory neurotransmitter receptors in the mammalian brain and are activated in a variety of normal neurophysiologic processes. This gene product belongs to a family of glutamate receptors that are sensitive to alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate (AMPA), and function as ligand-activated cation channels. These channels are assembled from 4 related subunits, GRIA1-4. The subunit encoded by this gene (GRIA2) is subject to RNA editing (CAG->CGG; Q->R) within the second transmembrane domain, which is thought to render the channel impermeable to Ca(2+). Human and animal studies suggest that pre-mRNA editing is essential for brain function, and defective GRIA2 RNA editing at the Q/R site may be relevant to amyotrophic lateral sclerosis (ALS) etiology. Alternative splicing, resulting in transcript variants encoding different isoforms, (including the flip and flop isoforms that vary in their signal transduction properties), has been noted for this gene. [provided by RefSeq].
Related Pathway

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WB Image
Western blot - GluR2 antibody [EP966Y]; Anti-Ionotropic Glutamate receptor 2 antibody [EP966Y] at 1/2000 dilution + Human brain cell lysate at 10 µg.Secondary.Goat anti-Rabbit HRP labeled at 1/2000 dilution.Predicted band size : 99 kDa.Observed band size : 110 kDa .
WB Image
Western blot - Anti-Ionotropic Glutamate receptor 2 antibody [EP966Y]; All lanes : Anti-Ionotropic Glutamate receptor 2 antibody [EP966Y] at 1/500 dilution.Lane 1 : Human Brain.Lane 2 : Rat Brain.Lane 3 : Mouse Brain.Predicted band size : 99 kDa.

 

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