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Home Antibody All anti-GRIA1 antibodies

Anti-GRIA1 PHOSPHO Antibody EPR2148

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Specifications Citations Related Products Product Documents
SKU Description Amount Price Availability*  
TA301319
  • Rabbit Monoclonal Antibody against GRIA1 (Clone EPR2148) (Phospho-specific)
100ul 325 3-7 Days
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WB(1)

OriGene Data

ImmunogenA phospho-specific peptide corresponding to residues surrounding Serine 845 of human GluR1 was used as an immunogen. The antibody only detects GluR1 phosphorylated on Serine 845.
Clone NameEPR2148 IsotypeIgG
Species ReactivityMouse, Rat, Human ConcentrationLot dependent; please refer to CoA along with shipment
Guaranteed Application *WB Suggested DilutionsWB: 1:1000 - 1:10000
BufferPBS 49%,Sodium azide 0.01%,Glycerol 50%,BSA 0.05%
Purification Tissue culture supernatant
Note Is unsuitable for Flow Cyt,ICC,IHC-P or IP.

Reference Data

Target NameHomo sapiens glutamate receptor, ionotropic, AMPA 1 (GRIA1), transcript variant 1
Alternative NameGluA1; GLUH1; GLUR1; GLURA; HBGR1
Database LinkNP_000818
FunctionGlutamic acid is the major excitatory neurotransmitter in the mammalian central nervous system. Glutamate receptors are classified on the basis of their activation by different agonists (1-3). GluR1, human glutamate receptor type 1, is an integral membrane protein that is widely expressed in the human brain. The postsynaptic actions of glutamic acid are mediated by a variety of receptors that are named according to their selective agonists. GluR1 is known to bind a kainate subtype of agonist. It has been found that malfunctioning of the glutamatergic system may result in certain brain disorders and neurodegeneration (3). Phosphorylation of the GluR1 subunit on serine 845 by PKA is required for PKA-induced increases in ?-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptor cell-surface expression because it promotes receptor insertion and decreases receptor endocytosis. Furthermore, dephosphorylation of GluR1 serine 845 triggers NMDA-induced AMPA receptor internalization (4).
Related Pathway

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WB Image
Western blot - Glutamate Receptor 1 (AMPA subtype) (phospho S845) antibody [EPR2148]; All lanes : Anti-Glutamate Receptor 1 (AMPA subtype) (phospho S845) antibody [EPR2148] at 1/20000 dilution.Lane 1 : Rat brain lysate, untreated.Lane 2 : Rat brain lysate treated with Lambda Phosphatase.Lysates/proteins at 10 ug per lane.Secondary.Goat anti-rabbit HRP at 1/1000 dilution.Predicted band size : 102 kDa.Observed band size : 106 kDa .

 

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