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Anti-GRB7 Antibody EPR4378
Also for GRB7 (NM_005310)
|A synthetic peptide corresponding to residues in human GRB7 was used as an immunogen.|
|Human, Mouse, Rat
||Lot dependent; please refer to CoA along with shipment
||WB: 1:1000 - 1:10000; IHC-P: 1:50 - 1:100; ICC: 1:50 - 1:100
|PBS 49%,Sodium azide 0.01%,Glycerol 50%,BSA 0.05%|
|Tissue culture supernatant
|Is unsuitable for Flow Cyt or IP.
|Homo sapiens growth factor receptor-bound protein 7 (GRB7), transcript variant 1|
|OTTHUMP00000164352; growth factor receptor-bound protein 7|
|GRB7 (Growth factor receptor-bound protein 7) belongs to a small family of adaptor proteins that are known to interact with a number of receptor tyrosine kinases and signaling molecules. It interacts with epidermal growth factor receptor (EGFR) and ephrin receptors. The protein also plays a role in the integrin signaling pathway and cell migration by binding with focal adhesion kinase (FAK) (1). Best known for its regulatory role in cell migration and tumor metastasis, GRB7 regulates inflammation by coupling NF-kappaB-inducing kinase with erbB/EGFR family receptors (2). The role of Grb7 in these processes depends upon binding to membrane-associated tyrosine kinases through its C-terminal SH2 domain (2). Aberrant overexpression of GRB7 has been found in numerous human cancers, including ovarian cancer (3).|
EGFR1 Signaling Pathway
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Western blot - GRB7 antibody [EPR4378]; All lanes : Anti-GRB7 antibody [EPR4378] at 1/1000 dilution.Lane 1 : SKBR-3 cell lysate.Lane 2 : HeLa cell lysate.Lysates/proteins at 10 µg per lane.Secondary.HRP-labelled Goat anti-Rabbit at 1/2000 dilution.Predicted band size : 60 kDa.
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - GRB7 antibody [EPR4378]; TA307229 at 1/50 dilution staining GRB7 in paraffin-embedded Human breast tissue by Immunohistochemistry.