Novel HIF2A mutations disrupt oxygen sensing, leading to polycythemia, paragangliomas, and somatostatinomas Blood, Mar 2013; 121: 2563 - 2566.
[anti-HA]
Regulation of the PI3-K/Akt Survival Pathway in the Rat Endometrium Biol Reprod, Mar 2013; 88: 79.
[Akt3]
RNA elements directing in vivo assembly of the 7SK/MePCE/Larp7 transcriptional regulatory snRNP Nucleic Acids Res., Mar 2013; 10.1093/nar/gkt159.
[LA]
Ruxolitinib as potential targeted therapy for patients with JAK2 rearrangements Haematologica, Mar 2013; 98: 404 - 408.
[JAK2]
Homo sapiens growth factor receptor-bound protein 7 (GRB7), transcript variant 1
Synonyms:
OTTHUMP00000164352; growth factor receptor-bound protein 7
Immunogen
A synthetic peptide corresponding to residues in human GRB7 was used as an immunogen.
Buffer
Store at -20C. Buffer: 50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA. Stable for 12 months from date of receipt.
GRB7 (Growth factor receptor-bound protein 7) belongs to a small family of adaptor proteins that are known to interact with a number of receptor tyrosine kinases and signaling molecules. It interacts with epidermal growth factor receptor (EGFR) and ephrin receptors. The protein also plays a role in the integrin signaling pathway and cell migration by binding with focal adhesion kinase (FAK) (1). Best known for its regulatory role in cell migration and tumor metastasis, GRB7 regulates inflammation by coupling NF-kappaB-inducing kinase with erbB/EGFR family receptors (2). The role of Grb7 in these processes depends upon binding to membrane-associated tyrosine kinases through its C-terminal SH2 domain (2). Aberrant overexpression of GRB7 has been found in numerous human cancers, including ovarian cancer (3).
Related Pathway
EGFR1 Signaling Pathway
Hemostasis
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