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Anti-GPX4 Antibody


Specifications Citations Customer Reviews Product Documents
SKU Description Amount Price Availability*  
TA319336 Rabbit polyclonal Glutathione Peroxidase 4 antibody 100ug $325 3-7 Days
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OriGene Data

ImmunogenThis affinity purified antibody was prepared from whole rabbit serum produced by repeated immunizations with a synthetic peptide corresponding to amino acids near the carboxyl terminus of mouse GPx4 protein.
Clone Name IsotypeIgG
Species Reactivitymouse, rat, guinea pig Concentration1.15 mg/mL
Guaranteed Application *WB Suggested DilutionsELISA: 1:7,000 - 1:30,000, WB: 1:500 - 1:3,000, IHC: User Optimized
Buffer0.02 M Potassium Phosphate, 0.15 M Sodium Chloride, pH 7.2
Note This antibody is suitable for Cancer, Immunology and Nuclear Signaling research. Glutathione Peroxidase 4 (GPx4, also known as PHGPx) functions as an antioxidant and also plays a role in redox regulation, sexual maturation, inflammation, apoptosis, and differentiation.  GPx4 was found to have an important role in preventing lipid peroxidation, and has been discussed primarily as the glutathione peroxidase protecting biomembranes against oxidative stress.  GPx4 can react with free hydrogen peroxide as well as with a wide range of lipid hydroperoxides, including those derived from cholesterol and cholesteryl esters.  GPx4 is the only GPx to use phospholipid hydroperoxides as substrates.  It can also reduce thymine hydroperoxide. In contrast to GPx1 and GPx3, GPx4 can use a wide range of reducing substrates in addition to glutathione.  GPx4 is expressed in high levels in testes, suggesting a role in male fertility.  It has also been identified as an enzymatically inactive structural protein of the mitochondrial capsule of sperm.

Reference Data

Target NameMus musculus glutathione peroxidase 4 (Gpx4), transcript variant 2
Alternative NameGPx-4; GSHPx-4; mtPHGPx; PHGPx; snGPx
Database LinkNP_032188
Entrez Gene 625249 Mouse
Entrez Gene 29328 Rat
Related Pathway

* Availability is in business days
* OriGene provides validated application data and protocol, with money back guarantee.

WB Image
Western blot using affinity purified anti-GPx4 to detect GPx4 in testis extract (arrow). Tissue extract (40 µg) was electrophoresed and transferred to nitrocellulose. The membrane was probed with the primary antibody at a 1:1,000 dilution. Personal Communication, Dolph Hatfield, CCR-NCI, Bethesda, MD.


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