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Home Antibody All anti-GPR3 antibodies

Anti-GPR3 Antibody

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Specifications Citations Related Products Product Documents
SKU Description Amount Price Availability*  
TA306784
  • Rabbit Polyclonal GPR3 Antibody
  • Free Sample of Positive Control: HEK293T cell transient overexpression lysate (LC417404) , 20ug Explanation
100ug 325 In Stock
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WB(1)
IHC(1)

OriGene Data

ImmunogenGPR3 antibody was raised against a 13 amino acid peptide from near the carboxy terminus of human GPR3.
Clone Name IsotypeIgG
Species ReactivityHuman, Mouse, Rat Concentration1 mg/ml
Guaranteed Application *WB, IHC Suggested DilutionsWB: 1 - 2 ug/ml
BufferPBS containing 0.02% sodium azide.
Purification Affinity chromatography purified via peptide column

Reference Data

Target NameHomo sapiens G protein-coupled receptor 3 (GPR3)
Alternative NameACCA
Database LinkNP_005272
Entrez Gene 2827 Human
Entrez Gene 14748 Mouse
Entrez Gene 266769 Rat
FunctionGPR3, also known as ACCA, is a G-protein coupled receptor that constitutively activates adenylate cyclase and is highly expressed in the central nervous system. Overexpression of GPR3 stimulates the production of amyloid-b peptide (Ab), the deposition of which is one of the pathological hallmarks of Alzheimer ’s disease (AD), while the ablation of GPR3 prevented the accumulation of Ab in vitro and in an AD mouse model. This is of particular interest because of the proximity of a reported candidate Alzheimer ’s disease (AD) locus, suggesting that GPR3 may be a potential therapeutic target for the treatment of AD. GPR3 has also been shown to block the proliferation of cerebellar granule cell precursors (GCP) during postnatal development by inhibiting the Shh-induced proliferation of GCP, indicating that GPR3 activation may represent one of the signals that triggers the postnatal cell cycle exit and terminal differentiation of GPCs.
Related PathwayGPCRTransmembraneDruggable Genome

* Availability is in business days
* OriGene provides validated application data and protocol, with money back guarantee.

WB Image
Western blot analysis of GPR3 in EL4 cell lysate with GPR3 antibody at (A) 1 and (B) 2 ug/ml.
IHC Image
Immunohistochemistry of GPR3 in human spleen tissue with GPR3 antibody at 2.5 ug/ml.

 

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