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Home Antibody All anti-GPR124 antibodies

Anti-GPR124 Antibody

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Specifications Citations Related Products Product Documents
SKU Description Amount Price Availability*  
TA306488
  • Rabbit Polyclonal TEM5 Antibody
  • Free Sample of Positive Control: HEK293T cell transient overexpression lysate (LC432439) , 20ug Explanation
100ug 325 3-7 Days
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WB(1)
IHC(1)
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Also for GPR124 (NM_032777)
cDNA Clone shRNA/siRNA Lysate Protein Antibody

OriGene Data

ImmunogenTEM5 antibody was raised against a 15 amino acid peptide near the carboxy terminus of the human TEM5.
Clone Name IsotypeIgG
Species ReactivityHuman, Rat Concentration1ug/ul
Guaranteed Application *WB, IHC Suggested DilutionsWB: 1 - 2 ug/ml
BufferPBS containing 0.02% sodium azide.
Purification Affinity chromatography purified via peptide column

Reference Data

Target NameHomo sapiens G protein-coupled receptor 124 (GPR124)
Alternative NameTEM5
Database LinkNP_116166
Entrez Gene 25960 Human
Entrez Gene 306543 Rat
FunctionTumor endothelial markers (TEMs) are significantly up-regulated during angiogenesis and neoangiogensis that are crucial for the growth of solid tumors. TEMs localized on the cell surface and conserved across species are of particular interest for future development of anti-angiogenic therapies. These include TEMs such as TEM1, TEM5, TEM7 and TEM8. TEM5 is a member of the adhesion family of G protein coupled receptors and is localized on the surface of endothelial cells. TEM5 is a seven-pass transmembrane receptor, unlike TEM1, TEM7 and TEM8 which span the membrane once. TEM5 is abundantly expressed in tumor vessels, heart, placenta, ovary, small intestine, and colon. Proteolytically processed soluble TEM5 mediates endothelial cell survival during angiogenesis by linking integrin to glycosaminoglycans.
Related PathwayTransmembraneDruggable Genome

* Availability is in business days
* OriGene provides validated application data and protocol, with money back guarantee.

WB Image
Western blot analysis of TEM5 in human bladder tissue lysate with TEM5 antibody at (A) 2 and (B) 4 ug/ml.
IHC Image
Immunohistochemistry of TEM5 in human bladder tissue with TEM5 antibody at 5 ug/ml.

 

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