The Golgi complex plays a key role in the sorting and modification of proteins exported from the endoplasmic reticulum. The protein encoded by this gene is a membrane protein involved in establishing the stacked structure of the Golgi apparatus. It is a caspase-3 substrate, and cleavage of this encoded protein contributes to Golgi fragmentation in apoptosis. This encoded protein can form a complex with the Golgi matrix protein GOLGA2, and this complex binds to the vesicle docking protein p115. Several alternatively spliced transcript variants of this gene have been identified, but their full-length natures have not been determined. [provided by RefSeq].
Related Pathway
Cell cycle
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HEK293T cells were transfected with the pCMV6-ENTRY control (Left lane) or pCMV6-ENTRY GORASP1 (RC210076, Right lane) cDNA for 48 hrs and lysed. Equivalent amounts of cell lysates (5 ug per lane) were separated by SDS-PAGE and immunoblotted with anti-GORASP1.
Immunohistochemical staining of paraffin-embedded Adenocarcinoma of Human colon tissue using anti-GORASP1 mouse monoclonal antibody. (TA501352, Dilution 1:50)
HEK293T cells transfected with either RC210076 overexpress plasmid(Red) or empty vector control plasmid(Blue) were immunostained by anti-GORASP1 antibody(TA501352), and then analyzed by flow cytometry.
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