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Home Antibody All anti-GOPC antibodies

Anti-GOPC Antibody

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Specifications Citations Related Products Product Documents
SKU Description Amount Price Availability*  
TA306263
  • Rabbit Polyclonal PIST Antibody
100ug 325 3-7 Days
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WB(1)
IHC(1)

OriGene Data

ImmunogenPIST antibody was raised against a 16 amino acid peptide from near the carboxy terminus of human PIST.
Clone Name IsotypeIgG
Species ReactivityHuman, Mouse, Rat Concentration1ug/ul
Guaranteed Application *WB, IHC Suggested DilutionsWB: 1 - 2 ug/ml
BufferPBS containing 0.02% sodium azide.
Purification Affinity chromatography purified via peptide column

Reference Data

Target NameHomo sapiens golgi-associated PDZ and coiled-coil motif containing (GOPC), transcript variant 2
Alternative NameCAL; dJ94G16.2; FIG; GOPC1; PIST
Database LinkNP_001017408
FunctionAutophagy, the process of bulk degradation of cellular proteins through an autophagosomic-lysosomal pathway is important for normal growth control and may be defective in tumor cells. It is involved in the preservation of cellular nutrients under starvation conditions as well as the normal turnover of cytosolic components (1,2) and is negatively regulated by TOR (Target of rapamycin) (3). PIST, a PDZ-containing protein, was discovered in a yeast two-hybrid system as a binding partner to Beclin-1, a Bcl-2-interacting protein homologous to the yeast autophagy gene apg6 (4-6). Experiments with mutant PIST proteins lacking the PDZ domain showed that PIST interaction with Beclin-1 through its coiled-coil domain can modulate Beclin-1 activity and suggest that PIST interactions with other proteins through its PDZ domain may regulate the activity of PIST and Beclin-1 (6).
Related Pathway

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WB Image
Western blot analysis of PIST in rat colon cell lysate with PIST antibody at (A) 1, (B) 2 and (C) 4 ug/ml.
IHC Image
Immunohistochemistry of PIST in rat colon tissue with PIST antibody at 1 ug/ml.

 

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