The protein encoded by this gene is an enzyme that catalyzes the conversion of S-adenosyl-L-methionine (along with glycine) to S-adenosyl-L-homocysteine and sarcosine. The encoded protein is found in the cytoplasm and acts as a homotetramer. Defects in this gene are a cause of GNMT deficiency (hypermethioninemia).
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HEK293T cells were transfected with the pCMV6-ENTRY control (Left lane) or pCMV6-ENTRY GNMT (RC207497, Right lane) cDNA for 48 hrs and lysed. Equivalent amounts of cell lysates (5 ug per lane) were separated by SDS-PAGE and immunoblotted with anti-GNMT.
HEK293T cells transfected with either pCMV6-ENTRY GNMT(RC207497)(Red) or empty vector control plasmid(Blue) were immunostained with anti-GNMT mouse monoclonal(TA501276), and then analyzed by flow cytometry.
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