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Anti-GNB2 Antibody EPR3261Y
Also for GNB2 (NM_005273)
|A peptide corresponding to residues near N-term of human GNB2 was used as an immunogen.|
|Human, Mouse, Rat
||Lot dependent; please refer to CoA along with shipment
||IHC-P: Use at an assay dependent dilution; WB: 1:5000 - 1:20000; ICC: 1:100 - 1:250; FC: 1:50; IP: 1:20
|PBS 49%,Sodium azide 0.01%,Glycerol 50%,BSA 0.05%|
|Tissue culture supernatant
|Homo sapiens guanine nucleotide binding protein (G protein), beta polypeptide 2 (GNB2)|
|G protein, beta-2 subunit; OTTHUMP00000174601; OTTHUMP00000174602; guanine nucleotide-binding protein G(I)/G(S)/G(T) beta subunit 2; guanine nucleotide-binding protein, beta-2 subunit; signal-transducing guanine nucleotide-binding regulatory protein beta|
|Guanine nucleotide binding protein beta-2 (GNB2) is a G-protein subunit belonging to WD repeat G protein beta family. GNB2 functions as a modulator or transducer for trans-membrane signaling pathway systems. G-protein is composed of alpha, beta, and gamma subunits, where beta and gamma subunits are required for GTPase activity and G-protein effector interaction (1). Specifically, GNB2 interacts with the glucocorticoid and migrates into the nucleus to suppress GR-induced trans-activation of the glucocorticoid-responsive genes (2). GNB2 has been identified as a binding partner to Ataxin 10, an important target in SCA10 disorder, and also a partner in regulating NTE, a protein known to cause delayed neuropathy with degeneration of nerve axon (3, 4).|
Signaling by GPCR
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Western blot - GNB2 antibody [EPR3261Y]; All lanes : Anti-GNB2 antibody [EPR3261Y] at 1/20000 dilution.Lane 1 : SHSY5Y cell lysates.Lane 2 : Jurkat cell lysates.Lane 3 : NIH3T3 cell lysates.Lysates/proteins at 10 µg per lane.Secondary.Goat anti-rabbit HRP labelled IgG at 1/2000 dilution.Predicted band size : 37 kDa.Observed band size : 35 kDa .