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Home Antibody All anti-GNAS antibodies

Anti-GNAS Antibody


Specifications Citations Customer Reviews Product Documents
SKU Description Amount Price Availability*  
TA308889 Rabbit Polyclonal antibody to GNAS (GNAS complex locus) 100ul $325 In Stock
LC424674 GNAS HEK293T cell transient overexpression lysate (as WB positive control) 20ug $50 In Stock
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OriGene Data

ImmunogenRecombinant fragment corresponding to a region within amino acids 716 and 998 of GNAS (Uniprot ID#Q5JWF2)
Clone Name IsotypeIgG
Species ReactivityHuman, Mouse (Predicted: Rat, Dog, Pig, Bovine) ConcentrationLot dependent; please refer to CoA along with shipment
Guaranteed Application *WB, IHC Suggested DilutionsIHC:1:100-1:1000; WB:1:500-1:3000
Predicted MW Explanation 111kDa
Buffer0.1M Tris, 0.1M Glycine, 10% Glycerol (pH7). 0.01% Thimerosal was added as a preservative.
Purification Purified by antigen-affinity chromatography.
Note Seq homology of immunogen across species: Rat (100%), Dog (100%), Pig (100%), Bovine (100%)

Reference Data

Target NameHomo sapiens GNAS complex locus (GNAS), transcript variant 1
Alternative NameAHO; C20orf45; GNAS1; GPSA; GSA; GSP; NESP; PHP1A; PHP1B; PHP1C; POH; SgVI
Database LinkNP_000507
Entrez Gene 2778 Human
Entrez Gene 14683 Mouse
Entrez Gene 24896 Rat
Entrez Gene 403943 Dog
FunctionThis locus has a highly complex imprinted expression pattern. It gives rise to maternally, paternally, and biallelically expressed transcripts that are derived from four alternative promoters and 5' exons. Some transcripts contains a differentially methylated region (DMR) at their 5' exons, and this DMR is commonly found in imprinted genes and correlates with transcript expression. An antisense transcript is produced from an overlapping locus on the opposite strand. One of the transcripts produced from this locus, and the antisense transcript, are paternally expressed noncoding RNAs, and may regulate imprinting in this region. In addition, one of the transcripts contains a second overlapping ORF, which encodes a structurally unrelated protein - Alex. Alternative splicing of downstream exons is also observed, which results in different forms of the stimulatory G-protein alpha subunit, a key element of the classical signal transduction pathway linking receptor-ligand interactions with the activation of adenylyl cyclase and a variety of cellular reponses. Multiple transcript variants encoding different isoforms have been found for this gene. Mutations in this gene result in pseudohypoparathyroidism type 1a, pseudohypoparathyroidism type 1b, Albright hereditary osteodystrophy, pseudopseudohypoparathyroidism, McCune-Albright syndrome, progressive osseus heteroplasia, polyostotic fibrous dysplasia of bone, and some pituitary tumors. [provided by RefSeq]
Related PathwaySecreted ProteinDruggable Genome Calcium signaling pathwayVascular smooth muscle contractionGap junctionLong-term depressionTaste transductionGnRH signaling pathwayMore Pathways >>

* Availability is in business days
* OriGene provides validated application data and protocol, with money back guarantee.

WB Image
Sample (50 ug of whole cell lysate). . A: Mouse brain. . 10% SDS PAGE. . TA308889 diluted at 1:1000.

WB Image
GNAS antibody [C2C3], C-term detects GNAS protein by Western blot analysis. A. 30 ug IMR32 whole cell lysate/extract. 10 % SDS-PAGE. GNAS antibody [C2C3], C-term (TA308889) dilution: 1:500.

IHC Image
Immunohistochemical analysis of paraffin-embedded OVCA, using GNAS(TA308889) antibody at 1:100 dilution.


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