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Home Antibody All anti-GNAS antibodies

Anti-GNAS Antibody

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SKU Description Amount Price Availability*  
TA308888 Rabbit Polyclonal antibody to GNAS (GNAS complex locus) 100ul $325 3-7 Days
LC424674 GNAS HEK293T cell transient overexpression lysate (as WB positive control) 20ug $50 In Stock
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WB(4)
IHC(1)

OriGene Data

ImmunogenRecombinant fragment corresponding to a region within amino acids 807 and 1037 of GNAS (Uniprot ID#Q5JWF2)
Clone Name IsotypeIgG
Species ReactivityHuman, Mouse (Predicted: Dog, Pig, Bovine) Concentration1mg/ml
Guaranteed Application *WB, IHC Suggested DilutionsIHC:1:100-1:1000; WB:1:500-1:3000
Predicted MW Explanation 46kDa
Buffer0.1M Tris, 0.1M Glycine, 10% Glycerol (pH7). 0.01% Thimerosal was added as a preservative.
Purification Purified by antigen-affinity chromatography.
Note Seq homology of immunogen across species: Dog (100%), Pig (100%), Bovine (100%)

Reference Data

Target NameHomo sapiens GNAS complex locus (GNAS), transcript variant 1
Alternative NameAHO; C20orf45; GNAS1; GPSA; GSA; GSP; NESP; PHP1A; PHP1B; PHP1C; POH; SgVI
Database LinkNP_000507
Entrez Gene 2778 Human
Entrez Gene 14683 Mouse
Entrez Gene 403943 Dog
FunctionThis locus has a highly complex imprinted expression pattern. It gives rise to maternally, paternally, and biallelically expressed transcripts that are derived from four alternative promoters and 5' exons. Some transcripts contains a differentially methylated region (DMR) at their 5' exons, and this DMR is commonly found in imprinted genes and correlates with transcript expression. An antisense transcript is produced from an overlapping locus on the opposite strand. One of the transcripts produced from this locus, and the antisense transcript, are paternally expressed noncoding RNAs, and may regulate imprinting in this region. In addition, one of the transcripts contains a second overlapping ORF, which encodes a structurally unrelated protein - Alex. Alternative splicing of downstream exons is also observed, which results in different forms of the stimulatory G-protein alpha subunit, a key element of the classical signal transduction pathway linking receptor-ligand interactions with the activation of adenylyl cyclase and a variety of cellular reponses. Multiple transcript variants encoding different isoforms have been found for this gene. Mutations in this gene result in pseudohypoparathyroidism type 1a, pseudohypoparathyroidism type 1b, Albright hereditary osteodystrophy, pseudopseudohypoparathyroidism, McCune-Albright syndrome, progressive osseus heteroplasia, polyostotic fibrous dysplasia of bone, and some pituitary tumors. [provided by RefSeq]
Related PathwaySecreted ProteinDruggable Genome Calcium signaling pathwayVascular smooth muscle contractionGap junctionLong-term depressionTaste transductionGnRH signaling pathwayMore Pathways >>

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* OriGene provides validated application data and protocol, with money back guarantee.

Sample (50 ug of whole cell lysate). A: Mouse brain. 10% SDS PAGE. TA308888 diluted at 1:1000.
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Sample (30 ug of whole cell lysate). A: Hep G2 . B: Raji. 10% SDS PAGE. TA308888 diluted at 1:1000.
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GNAS antibody [C2C3-2], C-term detects GNAS protein by Western blot analysis. A. 50 ug rat brain lysate/extract. 10 % SDS-PAGE. GNAS antibody [C2C3-2], C-term (TA308888) dilution: 1:1000
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GNAS antibody [C2C3-2], C-term detects GNAS protein by Western blot analysis. A. 30 ug NIH-3T3 whole cell lysate/extract. B. 30 ug JC whole cell lysate/extract. 12 % SDS-PAGE. GNAS antibody [C2C3-2], C-term (TA308888) dilution: 1:1000
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Immunohistochemical analysis of paraffin-embedded Colon ca, using GNAS(TA308888) antibody at 1:500 dilution.
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