Home Antibody All anti-GNAI2 antibodies
Also for GNAI2 (NM_002070)
|Synthetic peptide surrounding amino acid 229 of human Gai2|
||WB: 0.5-4ug/ml, IP: 10-20ug/ml
|100 µg (0.5 mg/ml) affinity-purified rabbit anti-Gai2 polyclonal antibody in phosphate buffered saline (PBS), pH 7.2, containing 30% glycerol, 0.5% BSA, 0.01% thimerosal.|
|Homo sapiens guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2 (GNAI2), transcript variant 1|
|GIP; GNAI2B; H_LUCA15.1; H_LUCA16.1|
|Gai2 is a 40-41 kDa alpha-subunit of heterotrimeric protein that shares sequence homology with Gai3 and Gai1. All these G proteins can be ADP-ribosylated at the carboxy terminal Cys of the CAAX sequence, interfering with receptor coupling. Gai2 is expressed widely in tissues and cell lines. Activation of PLC-ß by Gai-coupled receptors is the result of release of Gßg subunits from Gai. Gai2 regulates potassium channel activation. Mutation at Arg179 has been identified in tumors. This and the Q205L mutant inhibit adenylyl cyclase.|
Signaling by GPCR
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Western blot analysis of G alpha i2 expression in 3T3 cell lysate.