Home Antibody All anti-GLS2 antibodies
Anti-GLS2 Antibody Polyclonal
Also for GLS2 (NM_013267)
|GLS2 antibody was raised against a 18 amino acid synthetic peptide near the center terminus of human GLS2.|
|Human, Mouse, Rat
||ELISA, WB: 0.5 - 1 ug/ml, IHC: 5 ug/ml, IF: 20 ug/ml
|GLS2 Antibody is supplied in PBS containing 0.02% sodium azide.|
|GLS2 Antibody is affinity chromatography purified via peptide column.
|Homo sapiens glutaminase 2 (liver, mitochondrial) (GLS2), transcript variant 1|
|GA; GLS; hLGA; LGA|
Entrez Gene 27165 Human
Entrez Gene 216456 Mouse
Entrez Gene 192268 Rat
|GLS2 Antibody: Phosphate-activated glutaminase, also known as Glutaminase 2 (GLS2), was initially isolated from rat liver, although it has been shown to be expressed in other tissues. Like the functionally similar, larger kidney glutaminase, GLS2 catalyzes the hydrolysis of glutamine to stoichiometric amounts of glutamate and ammonia. Expression of GLS2 is increased by p53 under both stressed and nonstressed conditions, resulting in increased levels of glutamate and alpha-ketoglutarate, which in turn results in enhanced mitochondrial respiration and ATP generation. GLS2 also regulates antioxidant defense function in cells by increasing reduced glutathione levels and decreasing ROS-levels, suggesting that GLS2 acts as a mediator of p53's role in antioxidant defense in addition to its role in energy metabolism.|
| Alanine, aspartate and glutamate metabolismArginine and proline metabolismD-Glutamine and D-glutamate metabolismNitrogen metabolismMetabolic pathways|
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Western blot analysis of GLS2 in rat kidney tissue lysate with GLS2 antibody at (A) 0.5 and (B) 1 ug/mL.
Immunohistochemistry of GLS2 in human kidney tissue with GLS2 antibody at 5 ug/mL.