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Anti-GLDC Antibody


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SKU Description Amount Price Availability*  
  • Rabbit Polyclonal antibody to Glycine dehydrogenase (glycine dehydrogenase (decarboxylating))
  • Free Sample of Positive Control: HEK293T cell transient overexpression lysate (LC424873) , 20ug Explanation
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OriGene Data

ImmunogenRecombinant fragment corresponding to a region within amino acids 442 and 723 of Glycine dehydrogenase (Uniprot ID#P23378)
Clone Name IsotypeIgG
Species ReactivityHuman (Predicted: Mouse, Chicken, Rat, Xenopus laevis, Bovine) ConcentrationLot dependent; please refer to CoA along with shipment
Guaranteed Application *WB, IHC, IF Suggested DilutionsICC/IF:1:100-1:1000; IHC:1:100-1:1000; WB:1:500-1:3000
Predicted MW Explanation 113kDa
Buffer0.1M Tris, 0.1M Glycine, 10% Glycerol (pH7). 0.01% Thimerosal was added as a preservative.
Purification Purified by antigen-affinity chromatography.
Note Seq homology of immunogen across species: Mouse (91%), Chicken (85%), Rat (84%), Xenopus laevis (86%), Bovine (92%)

Reference Data

Target NameHomo sapiens glycine dehydrogenase (decarboxylating) (GLDC)
Alternative NameGCE; GCSP; HYGN1
Database LinkNP_000161
Entrez Gene 2731 Human
Entrez Gene 104174 Mouse
Entrez Gene 309312 Rat
FunctionThe enzyme system for cleavage of glycine (glycine cleavage system; GCS; EC, which is confined to the mitochondria, is composed of 4 protein components: P protein (a pyridoxal phosphate-dependent glycine decarboxylase), H protein (a lipoic acid-containing protein), T protein (a tetrahydrofolate-requiring enzyme), and L protein (a lipoamide dehydrogenase). Glycine encephalopathy (GCE; MIM 605899) may be due to a defect in any one of these enzymes; see MIM 238310, MIM 238330, and MIM 238331.[supplied by OMIM]
Related PathwayDruggable Genome Glycine, serine and threonine metabolismMetabolic pathways

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WB Image
Glycine dehydrogenase antibody detects Glycine dehydrogenase protein by western blot analysis. A. 30 ug HeLa whole cell lysate/extract. B. 30 ug HepG2 whole cell lysate/extract. 5 % SDS-PAGE. Glycine dehydrogenase antibody (TA308885) dilution: 1:500
IHC Image
Immunohistochemical analysis of paraffin-embedded A549 xenograft, using Glycine dehydrogenase(TA308885) antibody at 1:500 dilution.
IF Image
Glycine dehydrogenase antibody [N3C2-2], Internal detects Glycine dehydrogenase protein at mitochondria by immunofluorescent analysis. Sample: HepG2 cells were fixed in ice-cold MeOH for 5 min. Green: Glycine dehydrogenase protein stained by Glycine dehyd


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