Home Antibody All anti-GFRA2 antibodies
Also for GFRA2 (NM_001165038)
|GFR alpha 2 antibody was raised against a peptide corresponding to amino acids 377 to 391 of human GFR alpha 2. The amino acid sequences of immunogenic peptide are identical to those of mouse and rat.|
|Human, Mouse, Rat
||ELISA, WB: 1 ug/ml, ICC: 5 ug/ml
|PBS containing 0.02% sodium azide.|
|Antibody is DEAE purified
|Homo sapiens GDNF family receptor alpha 2 (GFRA2), transcript variant 2|
|GDNFRB; NRTNR-ALPHA; NTNRA; RETL2; TRNR2|
Entrez Gene 2675 Human
Entrez Gene 14586 Mouse
Entrez Gene 25136 Rat
|Members of the glial cell line-derived neurotrophic factor (GDNF) family, including GDNF and neurturin (NTN), play key roles in the control of vertebrate neuron survival and differentiation. Physiological responses to NTN require the presence of a novel glycosylphosphadidylinositol linked protein NTNRalpha, which is a cell surface receptor for NTN. The cDNAs encoding NTNRa from human, rat, chicken, and mouse have been cloned recently. NTNRalpha was also termed GDNFRbeta, Ret ligand 2 (RETL2) or TGFbeta-related neurotrophic factor receptor 2 (TrnR2) and nominated as GFRalpha-2 recently. GFRalpha-2 binds NTN and mediates activation of RET receptor tyrosine kinase by both NTN and GDNF. Thus, NTN, GFRalpha-2, and the Ret PTK form a complex to transduce NTN signal and to mediate NTN function.|
|Druggable Genome |
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Western blot analysis of GFR alpha 2 in HeLa total cell lysate with GFR alpha 2 antibody at 1:1000 dilution.
Immunocytochemistry of GFR alpha 2 in HeLa cells with GFR alpha 2 antibody at 5 ug/mL.