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Home Antibody All anti-GFRA2 antibodies

Anti-GFRA2 Antibody

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Specifications Citations Related Products Product Documents
SKU Description Amount Price Availability*  
TA305953
  • Rabbit Polyclonal GFR alpha 2 Antibody
  • Free Sample of Positive Control: HEK293T cell transient overexpression lysate (LC431318) , 20ug Explanation
100ug 325 3-7 Days
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WB(1)
IF(1)
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Also for GFRA2 (NM_001165038)
cDNA Clone shRNA/siRNA Primer Pair Protein Antibody

OriGene Data

ImmunogenGFR alpha 2 antibody was raised against a peptide corresponding to amino acids 377 to 391 of human GFR alpha 2. The amino acid sequences of immunogenic peptide are identical to those of mouse and rat.
Clone Name IsotypeIgG
Species ReactivityHuman, Mouse, Rat Concentration1ug/ul
Guaranteed Application *WB, IF Suggested DilutionsELISA, WB: 1 ug/ml, ICC: 5 ug/ml
BufferPBS containing 0.02% sodium azide.
Purification Antibody is DEAE purified

Reference Data

Target NameHomo sapiens GDNF family receptor alpha 2 (GFRA2), transcript variant 2
Alternative NameGDNFRB; NRTNR-ALPHA; NTNRA; RETL2; TRNR2
Database LinkNP_001158510
Entrez Gene 2675 Human
Entrez Gene 14586 Mouse
Entrez Gene 25136 Rat
FunctionMembers of the glial cell line-derived neurotrophic factor (GDNF) family, including GDNF and neurturin (NTN), play key roles in the control of vertebrate neuron survival and differentiation. Physiological responses to NTN require the presence of a novel glycosylphosphadidylinositol linked protein NTNRalpha, which is a cell surface receptor for NTN. The cDNAs encoding NTNRa from human, rat, chicken, and mouse have been cloned recently. NTNRalpha was also termed GDNFRbeta, Ret ligand 2 (RETL2) or TGFbeta-related neurotrophic factor receptor 2 (TrnR2) and nominated as GFRalpha-2 recently. GFRalpha-2 binds NTN and mediates activation of RET receptor tyrosine kinase by both NTN and GDNF. Thus, NTN, GFRalpha-2, and the Ret PTK form a complex to transduce NTN signal and to mediate NTN function.
Related PathwayDruggable Genome

* Availability is in business days
* OriGene provides validated application data and protocol, with money back guarantee.

WB Image
Western blot analysis of GFR alpha 2 in HeLa total cell lysate with GFR alpha 2 antibody at 1:1000 dilution.
IF Image
Immunocytochemistry of GFR alpha 2 in HeLa cells with GFR alpha 2 antibody at 5 ug/mL.

 

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