Home Antibody All anti-GFRA1 antibodies
Also for GFRA1 (NM_001145453)
|GFR alpha 1 antibody was raised against a peptide corresponding to amino acids 369 to 382 of human GFR alpha 1.|
|Human, Mouse, Rat
||WB: 1:500; IHC: 1ug/ml
|PBS containing 0.02% sodium azide.|
|Antibody is DEAE purified (Protein A or G Sepharose)
|Homo sapiens GDNF family receptor alpha 1 (GFRA1), transcript variant 3|
|GDNFR; GDNFRA; GFR-ALPHA-1; RET1L; RETL1; TRNR1|
|Glial cell line-derived neurotrophic factor (GDNF) is a potent survival factor for central and peripheral neurons and is essential for the development of kidneys and the enteric nerves system. Physiological responses to GDNF require the presence of a novel glycosylphosphadidylinositol linked protein GDNFRa, which is a cell surface receptor for GDNF. The cDNAs encoding GDNFRalpha from human, rat, chicken and mouse have been cloned recently. GDNFRalpha was also termed Ret ligand 1 (RETL1) or TGF-beta-related neurotrophic factor receptor 1 (TrnR1) and nominated as GFRalpha-1 recently. GFRalpha-1 binds GDNF specifically and mediates activation of the Ret protein tyrosine kinase (PTK). Thus, GDNF, GFRalpha and the Ret PTK form a complex to transduce GDNF signal and to mediate GDNF function.|
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Western blot analysis of GFR alpha 1 in crude membrane fractions of human brain (B), liver (L), kidney (K), and spleen (S), respectively, with GFR alpha 1 antibody at 1:500 dilution.
Immunohistochemistry of GFRa-1 in human brain tissue with GFRa-1 antibody at 1 ug/ml.