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Home Antibody All anti-GFRA1 antibodies

Anti-GFRA1 Antibody

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Specifications Citations Related Products Product Documents
SKU Description Amount Price Availability*  
TA305952
  • Rabbit Polyclonal GFR alpha 1 Antibody
  • Free Sample of Positive Control: HEK293T cell transient overexpression lysate (LC428898) , 20ug Explanation
100ug 325 In Stock
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WB(1)
IHC(1)
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Also for GFRA1 (NM_001145453)
cDNA Clone shRNA/siRNA Lysate Protein Antibody

OriGene Data

ImmunogenGFR alpha 1 antibody was raised against a peptide corresponding to amino acids 369 to 382 of human GFR alpha 1.
Clone Name IsotypeIgG
Species ReactivityHuman, Mouse, Rat Concentration1mg/ml
Guaranteed Application *WB, IHC Suggested DilutionsWB: 1:500; IHC: 1ug/ml
BufferPBS containing 0.02% sodium azide.
Purification Antibody is DEAE purified

Reference Data

Target NameHomo sapiens GDNF family receptor alpha 1 (GFRA1), transcript variant 3
Alternative NameGDNFR; GDNFRA; GFR-ALPHA-1; RET1L; RETL1; TRNR1
Database LinkNP_001138925
Entrez Gene 2674 Human
Entrez Gene 14585 Mouse
Entrez Gene 25454 Rat
FunctionGlial cell line-derived neurotrophic factor (GDNF) is a potent survival factor for central and peripheral neurons and is essential for the development of kidneys and the enteric nerves system. Physiological responses to GDNF require the presence of a novel glycosylphosphadidylinositol linked protein GDNFRa, which is a cell surface receptor for GDNF. The cDNAs encoding GDNFRalpha from human, rat, chicken and mouse have been cloned recently. GDNFRalpha was also termed Ret ligand 1 (RETL1) or TGF-beta-related neurotrophic factor receptor 1 (TrnR1) and nominated as GFRalpha-1 recently. GFRalpha-1 binds GDNF specifically and mediates activation of the Ret protein tyrosine kinase (PTK). Thus, GDNF, GFRalpha and the Ret PTK form a complex to transduce GDNF signal and to mediate GDNF function.
Related Pathway

* Availability is in business days
* OriGene provides validated application data and protocol, with money back guarantee.

WB Image
Western blot analysis of GFR alpha 1 in crude membrane fractions of human brain (B), liver (L), kidney (K), and spleen (S), respectively, with GFR alpha 1 antibody at 1:500 dilution.
IHC Image
Immunohistochemistry of GFRa-1 in human brain tissue with GFRa-1 antibody at 1 ug/ml.

 

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