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Home Antibody All anti-GCLC antibodies

Anti-GCLC TRUEMAB Antibody Clone 1A3

TrueMAB™ Antibodies - Made against Authentic Protein Antigens

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Specifications Citations Related Products Product Documents
SKU Description Amount Price Availability*  
TA507318
  • GCLC mouse monoclonal antibody,clone 1A3
  • Free Sample of Positive Control: HEK293T cell transient overexpression lysate (LC419901) , 20ug
100ul 325 In Stock
CF507318
  • Carrier-free (glycerol/BSA-free) GCLC mouse monoclonal antibody,clone 1A3
100ug $450 3-4 Days
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WB(2)
IHC(3)
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Also for GCLC (NM_001498)
cDNA Clone shRNA/siRNA Lysate Protein Antibody

OriGene Data

ImmunogenFull length human recombinant protein of human GCLC(NP_001489) produced in HEK293T cell.
Clone NameClone 1A3 IsotypeIgG1
Species ReactivityHuman , Rat , Monkey Concentration1.00mg/ml
Guaranteed Application *WB, IHC Suggested Dilutions WB 1:200~1000, IHC 1:150,
BufferPBS (PH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.
Purification Purified from mouse ascites fluids by affinity chromatography

Reference Data

Target NameHomo sapiens glutamate-cysteine ligase, catalytic subunit (GCLC), transcript variant 1
Alternative NameGCL; GCS; GLCL; GLCLC
Database LinkNP_001489
FunctionGlutamate-cysteine ligase, also known as gamma-glutamylcysteine synthetase is the first rate-limiting enzyme of glutathione synthesis. The enzyme consists of two subunits, a heavy catalytic subunit and a light regulatory subunit. This locus encodes the catalytic subunit, while the regulatory subunit is derived from a different gene located on chromosome 1p22-p21. Mutations at this locus have been associated with hemolytic anemia due to deficiency of gamma-glutamylcysteine synthetase and susceptibility to myocardial infarction.[provided by RefSeq, Oct
Related Pathway

* Shipping is in business days
* OriGene provides validated application data and protocol, with money back guarantee.

WB Image
HEK293T cells were transfected with the pCMV6-ENTRY control (Left lane) or pCMV6-ENTRY GCLC (RC207915, Right lane) cDNA for 48 hrs and lysed. Equivalent amounts of cell lysates (5 ug per lane) were separated by SDS-PAGE and immunoblotted with anti-GCLC.
WB Image
Western blot analysis of extracts (35ug) from 9 different cell lines by using anti-GCLC monoclonal antibody (HepG2: human; HeLa: human; SVT2: mouse; A549: human; COS7: monkey; Jurkat: human; MDCK: canine; PC12: rat; MCF7: human).
IHC Image
Immunohistochemical staining of paraffin-embedded Human pancreas tissue using anti-GCLC mouse monoclonal antibody. (Heat-induced epitope retrieval by Tris-EDTA, pH8.0, TA507318)
IHC Image
Immunohistochemical staining of paraffin-embedded Carcinoma of Human thyroid tissue using anti-GCLC mouse monoclonal antibody. (Heat-induced epitope retrieval by Tris-EDTA, pH8.0, TA507318)
IHC Image
Immunohistochemical staining of paraffin-embedded Human lymph node tissue using anti-GCLC mouse monoclonal antibody. (Heat-induced epitope retrieval by Tris-EDTA, pH8.0, TA507318)

 

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