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Anti-GCG Antibody EPR4042


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SKU Description Amount Price Availability*  
  • Rabbit monoclonal antibody against Glucagon-like peptide 1 (GLP-1)(clone EPR4042)
  • Free Sample of Positive Control: HEK293T cell transient overexpression lysate (LC419562) , 20ug Explanation
100ul $325 3-7 Days
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OriGene Data

ImmunogenA synthetic peptide corresponding to residues in human Glucagon-like peptide 1 (GLP-1) was used as an immunogen.
Clone NameEPR4042 IsotypeIgG
Species ReactivityHuman (Does not react with: Mouse, Rat) ConcentrationLot dependent; please refer to CoA along with shipment
Guaranteed Application *WB, ELISA, IHC Suggested DilutionsELISA: Use a concentration of 1 ug/ml; WB: 1:200; IHC-P: 1:100 - 1:250
BufferPBS 49%,Sodium azide 0.01%,Glycerol 50%,BSA 0.05%
Note Is unsuitable for Flow Cyt,ICC or IP.

Reference Data

Target NameHomo sapiens glucagon (GCG)
Alternative NameGLP1; GLP2; GRPP
Database LinkNP_002045
Entrez Gene 2641 Human
FunctionGlucagon-like peptide 1 (GLP-1) is a gut hormone resulting from the proteolytic processing of preproglucagon (1). As a potent stimulator of glucose-dependent insulin release, it plays important roles in gastric motility and the suppression of plasma glucagon levels (2). GLP-1 increases islet mass through the stimulation of islet neogenesis and pancreatic beta cell proliferation (2). It also inhibits beta cell apoptosis (2). GLP-1 is secreted from intestinal L cells throughout the gastrointestinal tract and induced in response to nutrient ingestion (2). These physiological functions make GLP-1 a therapeutic target for type 2 diabetes, especially in the treatment of severe hypoglycemia in insulin-dependent diabetics (2).
Related PathwaySecreted ProteinES Cell Differentiation/IPSDruggable Genome

* Availability is in business days
* OriGene provides validated application data and protocol, with money back guarantee.

WB Image
Western blot - Anti-Glicentin antibody [EPR4042]; Anti-Glicentin antibody [EPR4042] at 1/200 dilution + Glicentin polypeptide at 0.005 ug.Predicted band size : 21 kDa.
ELISA - Anti-Glicentin antibody [EPR4042]; 1 ug/mL of Glucagon-like Peptide (GLP-1) was coated into 96-wells. Various concentrations of anti-Glucagon-Like Peptide 1 (GLP-1, 7-36,amide) rabbit monoclonal antibody was added. HRP conjugated goat anti-rabbit IgG antibody was used to develop the color.
IHC Image
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Glicentin antibody [EPR4042]; TA307487, at 1/100 dilution, staining Glicentin in Human pancreas tissue by immunohistochemistry


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