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Anti-GCG Antibody EP3070
|A synthetic peptide corresponding to residues in human Glucagon was used as an immunogen.|
|Human, Mouse, Rat
||0.5~1.0 mg/ml (Lot Dependent)
||WB: 1:1000 - 1:10000; IHC-P: 1:1000 - 1:5000
|PBS 49%,Sodium azide 0.01%,Glycerol 50%,BSA 0.05%|
|Tissue culture supernatant (Protein A or G Sepharose)
|Is unsuitable for Flow Cyt or IP.
|Homo sapiens glucagon (GCG)|
|GLP1; GLP2; GRPP|
|Glucagon is an important hormone involved in glucose metabolism and homeostasis (1). It regulates blood glucose by increasing gluconegenesis and decreasing glycolysis. It is synthesized and released by the alpha-cells of the islets of Langerhans in pancreas as the proglucagon and is preteolytically processed to yield the mature peptide (2). When the glucose level in the blood is low (hypoglycemia), Glucagon is released and binds to glucagon receptors on hepatocytes, causing the liver to release glucose through glycogenolysis. Upon the depletion of stored glycogen in the liver, Glucagon then stimulates liver to synthesize additional glucose by gluconeogenesis. It is a counter regulatory hormone of insulin, and plays an important role in initiating and maintaining hyperglycemic conditions in diabetes (3).|
Signaling by GPCR
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Western blot - Anti-Glucagon antibody [EP3070]; All lanes : Anti-Glucagon antibody [EP3070].Lane 1 : HepG2 Lysate.Lane 2 : Human Fetal liver lysate.Lane 3 : Mouse kidney lysate.Lane 4 : Mouse spleen Lysate.Predicted band size : 21 kDa.
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Glucagon antibody [EP3070]; ab92517, at 1/1000 dilution, staining Glucagon in paraffin embedded Human pancreas tissue by Immunohistochemistry.