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Anti-GCG Antibody EP3070


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SKU Description Amount Price Availability*  
  • Rabbit monoclonal antibody against Glucagon(clone EP3070)
  • Free Sample of Positive Control: HEK293T cell transient overexpression lysate (LC419562) , 20ug Explanation
100ul $325 3-7 Days
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OriGene Data

ImmunogenA synthetic peptide corresponding to residues in human Glucagon was used as an immunogen.
Clone NameEP3070 IsotypeIgG
Species ReactivityMouse, Rat, Human ConcentrationLot dependent; please refer to CoA along with shipment
Guaranteed Application *WB, IHC Suggested DilutionsWB: 1:1000 - 1:10000; IHC-P: 1:1000 - 1:5000
Predicted MW Explanation 21 kDa
BufferPBS 49%,Sodium azide 0.01%,Glycerol 50%,BSA 0.05%
Purification Tissue culture supernatant
Note Is unsuitable for Flow Cyt or IP.

Reference Data

Target NameHomo sapiens glucagon (GCG)
Alternative NameGLP1; GLP2; GRPP
Database LinkNP_002045
Entrez Gene 2641 Human
Entrez Gene 14526 Mouse
Entrez Gene 24952 Rat
FunctionGlucagon is an important hormone involved in glucose metabolism and homeostasis (1). It regulates blood glucose by increasing gluconegenesis and decreasing glycolysis. It is synthesized and released by the alpha-cells of the islets of Langerhans in pancreas as the proglucagon and is preteolytically processed to yield the mature peptide (2). When the glucose level in the blood is low (hypoglycemia), Glucagon is released and binds to glucagon receptors on hepatocytes, causing the liver to release glucose through glycogenolysis. Upon the depletion of stored glycogen in the liver, Glucagon then stimulates liver to synthesize additional glucose by gluconeogenesis. It is a counter regulatory hormone of insulin, and plays an important role in initiating and maintaining hyperglycemic conditions in diabetes (3).
Related PathwaySecreted ProteinES Cell Differentiation/IPSDruggable Genome

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* OriGene provides validated application data and protocol, with money back guarantee.

Western blot - Anti-Glucagon antibody [EP3070]; All lanes : Anti-Glucagon antibody [EP3070].Lane 1 : HepG2 Lysate.Lane 2 : Human Fetal liver lysate.Lane 3 : Mouse kidney lysate.Lane 4 : Mouse spleen Lysate.Predicted band size : 21 kDa.
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Glucagon antibody [EP3070]; TA307485, at 1/1000 dilution, staining Glucagon in paraffin embedded Human pancreas tissue by Immunohistochemistry.


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