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Home Antibody All anti-GBA3 antibodies

Anti-GBA3 TRUEMAB Antibody Clone OTI4G8

TrueMAB™ Antibodies - Made against Authentic Protein Antigens

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Specifications Citations (0) Related Products Product Documents
SKU Description Amount Price Availability*  
TA502542 GBA3 mouse monoclonal antibody, clone OTI4G8 (formerly 4G8) 100ul $325 In Stock
LC402815 GBA3 HEK293T cell transient overexpression lysate (as WB positive control) 20ug $50 In Stock
CF502542 Carrier-free (BSA/glycerol-free) GBA3 mouse monoclonal antibody, clone OTI4G8 (formerly 4G8) 100ug $450 3-4 weeks
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WB(1)
FC(3)

OriGene Data

ImmunogenHuman recombinant protein fragment corresponding to amino acids 1-150 and 370-469 of human GBA3 (NP_066024) produced in HEK293T cell.
Clone NameClone OTI4G8 IsotypeIgG1
Species ReactivityHuman Concentration0.84 mg/ml
Guaranteed Application *WB, FC Suggested DilutionsWB 1:500~2000, FLOW 1:100
Predicted MW Explanation 53.5 kDa
BufferPBS (PH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.
Purification Purified from mouse ascites fluids by affinity chromatography

Reference Data

Target NameHomo sapiens glucosidase, beta, acid 3 (gene/pseudogene) (GBA3), transcript variant 1
Alternative NameCBG; CBGL1; GLUC; KLRP
Database LinkNP_066024
Entrez Gene 57733 Human
FunctionGBA3, or cytosolic beta-glucosidase (EC 3.2.1.21), is a predominantly liver enzyme that efficiently hydrolyzes beta-D-glucoside and beta-D-galactoside, but not any known physiologic beta-glycoside, suggesting that it may be involved in detoxification of plant glycosides (de Graaf et al., 2001 [PubMed 11389701]). GBA3 also has significant neutral glycosylceramidase activity (EC 3.2.1.62), suggesting that it may be involved in a nonlysosomal catabolic pathway of glucosylceramide metabolism (Hayashi et al., 2007 [PubMed 17595169]).[supplied by OMIM].
Related Pathway Cyanoamino acid metabolismStarch and sucrose metabolism

* Availability is in business days
* OriGene provides validated application data and protocol, with money back guarantee.

HEK293T cells were transfected with the pCMV6-ENTRY control (Left lane) or pCMV6-ENTRY GBA3 (RC211035, Right lane) cDNA for 48 hrs and lysed. Equivalent amounts of cell lysates (5 ug per lane) were separated by SDS-PAGE and immunoblotted with anti-GBA3.
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HEK293T cells transfected with either RC211035 overexpress plasmid(Red) or empty vector control plasmid(Blue) were immunostained by anti-GBA3 antibody(TA502542), and then analyzed by flow cytometry.
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Flow cytometric Analysis of Hela cells, using anti-GBA3 antibody(TA502542),(Red), compared to a nonspecific negative control antibody(TA50011),(Blue).
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Flow cytometric Analysis of Jurkat cells, using anti-GBA3 antibody(TA502542),(Red), compared to a nonspecific negative control antibody(TA50011),(Blue).
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