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Home Antibody All anti-GATA3 antibodies

Anti-GATA3 Antibody TWAJ

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Specifications Citations Related Products Product Documents
SKU Description Amount Price Availability*  
TA320338
  • Rat Anti-Human/Mouse Gata-3 Purified (25 ug)
25ug 120 3-7 Days
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Also for GATA3 (NM_002051)
cDNA Clone shRNA/siRNA Lysate Protein Antibody

OriGene Data

Immunogen
Clone NameTWAJ Isotype
Species ReactivityHuman, Mouse Concentration0.5-1mg/ml (lot dependent)
Guaranteed Application *WB Suggested DilutionsICC, WB
BufferAqueous buffer, 0.09% sodium azide, may contain carrier protein/stabilizer
Purification Affinity purified

Reference Data

Target NameHomo sapiens GATA binding protein 3 (GATA3), transcript variant 2
Alternative NameHDR; HDRS
Database LinkNP_002042
Entrez Gene 2625 Human
Entrez Gene 14462 Mouse
FunctionThe monoclonal antibody TWAJ recognizes mouse and human Gata-3, a member of the Gata family of transcription factors. Gata-3 is a T cell-specific transcription factor important for thymic development and Th2 differentiation. Expression during embryonic development is found in the central nervous system, skin, mammary glands and kidney. During development, the expression of Gata-3 is essential as homozygous knock-out of Gata-3 is embryonic lethal. The Gata-3 is also essential for T cell commitment and survival. In the thymus, expression is found mainly on the CD4 single positive cells. During Th2 differentiation, Gata-3 binds to the IL-4 promoter as well as represses the expression of T-bet, thus inhibiting Th1 differentiation.Alternative splice variants have been reported especially in the MCF7 cell line. The TWAJ anti-mouse/human Gata-3 antibody will recognize both forms (50 and 45 kDa) of the protein.Staining with the TWAJ anti-mouse/human Gata-3 antibody requires the use of the Foxp3 Staining Buffer Set.
Related PathwayStem cell relevant signaling - JAK/STAT signaling pathwayES Cell Differentiation/IPSAdult stem cellsTranscription Factors

* Availability is in business days
* OriGene provides validated application data and protocol, with money back guarantee.

WB Image
Western blot using 2 ug/mL Anti-Human/Mouse Gata-3 Purified) and revealed with Anti-Rat IgG HRP. Lane 1: 3 day anti-CD3/CD28 stimulated human CD4 cells, 2: 6 day Th2 polarized cultured human cells, 3: Jurkat cell line, 4: MCF7 cell line

 

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