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Anti-GAP43 Antibody EP928Y


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SKU Description Amount Price Availability*  
  • Rabbit Monoclonal antibody against GAP43
100ul 325 3-7 Days
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OriGene Data

ImmunogenA synthetic peptide corresponding to residues surrounding serine 41 of human GAP43 was used as an immunogen. This antibody detects both phosphorylated and nonphosphorylated GAP43.
Clone NameEP928Y IsotypeIgG
Species ReactivityMouse, Rat, Human ConcentrationLot dependent; please refer to CoA along with shipment
Guaranteed Application *WB Suggested DilutionsWB: 1:1000; IP: 1:40;
BufferStore at -20 °C. Buffer: Antibody buffer, sodium azide, glycerol, and BSA. Stable for 12 months from date of receipt.

Reference Data

Target NameHomo sapiens growth associated protein 43 (GAP43), transcript variant 1
Alternative NameB-50; PP46
Database LinkNP_001123536
Entrez Gene 2596 Human
Entrez Gene 14432 Mouse
Entrez Gene 29423 Rat
FunctionGrowth associated protein GAP43 (B-50, F1, neuromodulin) is a phosphoprotein of the presynaptic membrane involved in synaptic reorganization and neural development. Phospholyated at Ser41 by protein kinase C (PKC), phospholyated GAP43 has been correlated to release of neurotransmitters in mature nervous system (1). Also, GAP43 plays an essential role in the maintenance mechanism of long-term potentiation (LTP) (2). These suggest GAP43 to play a role in synaptic plasticity. For neurons in development or regeneration, GAP43 is a major component of the growth cone, which enables elongation and navigation of developing axons (3). During periods of low activity in neurons, Calmodulin binds to GAP43 when Ca2+ is low, suggesting Calmodulin as a negative regulator of GAP43 (4).
Related Pathway

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* OriGene provides validated application data and protocol, with money back guarantee.

WB Image
Anti-GAP43 antibody [EP928Y] (TA310517) at 1/100000 dilution + human brain lysate at 10 ug. Secondary: HRP goat anti-rabbit at 1/2000 dilution


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