Home Antibody All anti-GALR2 antibodies
Also for GALR2 (NM_003857)
|Synthetic peptide contain a sequence corresponding to a region within amino acids 212 and 277 of Human GALR2|
||Lot dependent; please refer to CoA along with shipment
|0.1M Tris, 0.1M Glycine, 10% Glycerol (pH7). 0.01% Thimerosal was added as a preservative.|
|Purified by antigen-affinity chromatography.
|Homo sapiens galanin receptor 2 (GALR2)|
|GAL2-R; GALNR2; GALR-2|
|Galanin is an important neuromodulator present in the brain, gastrointestinal system, and hypothalamopituitary axis. It is a 30-amino acid non-C-terminally amidated peptide that potently stimulates growth hormone secretion, inhibits cardiac vagal slowing of heart rate, abolishes sinus arrhythmia, and inhibits postprandial gastrointestinal motility. The actions of galanin are mediated through interaction with specific membrane receptors that are members of the 7-transmembrane family of G protein-coupled receptors. GALR2 interacts with the N-terminal residues of the galanin peptide. The primary signaling mechanism for GALR2 is through the phospholipase C/protein kinase C pathway (via Gq), in contrast to GALR1, which communicates its intracellular signal by inhibition of adenylyl cyclase through Gi. However, it has been demonstrated that GALR2 couples efficiently to both the Gq and Gi proteins to simultaneously activate 2 independent signal transduction pathways. [provided by RefSeq]|
Signaling by GPCR
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Sample(30 ug whole cell lysate) A:293T B:H1299 (anti-GALR2 antibody diluted at 1:1000)
Immunohistochemical analysis of paraffin-embedded Skin, using Galanin Receptor 2(anti-GALR2 antibody) antibody(10 ?g/ml).