Home Antibody All anti-GALR2 antibodies
Also for GALR2 (NM_003857)
|Synthetic peptide corresponding to a region within amino acids 212 and 307 of Galanin Receptor 2 (Uniprot ID#O43603)|
|Human (Predicted: Mouse, Rat, Bovine)
||Lot dependent; please refer to CoA along with shipment
|0.1M Tris, 0.1M Glycine, 10% Glycerol (pH7). 0.01% Thimerosal was added as a preservative.|
|Purified by antigen-affinity chromatography.
|Seq homology of immunogen across species: Mouse (94%), Rat (94%), Bovine (94%)
|Homo sapiens galanin receptor 2 (GALR2)|
|GAL2-R; GALNR2; GALR-2|
Entrez Gene 8811 Human
Entrez Gene 14428 Mouse
Entrez Gene 29234 Rat
|Galanin is an important neuromodulator present in the brain, gastrointestinal system, and hypothalamopituitary axis. It is a 30-amino acid non-C-terminally amidated peptide that potently stimulates growth hormone secretion, inhibits cardiac vagal slowing of heart rate, abolishes sinus arrhythmia, and inhibits postprandial gastrointestinal motility. The actions of galanin are mediated through interaction with specific membrane receptors that are members of the 7-transmembrane family of G protein-coupled receptors. GALR2 interacts with the N-terminal residues of the galanin peptide. The primary signaling mechanism for GALR2 is through the phospholipase C/protein kinase C pathway (via Gq), in contrast to GALR1, which communicates its intracellular signal by inhibition of adenylyl cyclase through Gi. However, it has been demonstrated that GALR2 couples efficiently to both the Gq and Gi proteins to simultaneously activate 2 independent signal transduction pathways. [provided by RefSeq]|
|TransmembraneDruggable Genome Neuroactive ligand-receptor interaction|
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Sample(30 ug whole cell lysate). A:293T. B:H1299. 10% SDS PAGE. TA308347 diluted at 1:1000
Immunohistochemical analysis of paraffin-embedded Skin, using Galanin Receptor 2(TA308347) antibody(10 ug/ml).