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Anti-GAB2 Antibody EPR2869
Also for GAB2 (NM_012296)
|A synthetic peptide corresponding to residues in human Gab2 was used as an immunogen.|
|Human, Mouse, Rat
||0.5~1.0 mg/ml (Lot Dependent)
|WB, IHC, IF
||WB: 1:1000 - 1:10000; IHC-P: 1:100 - 1:250; ICC/IF: 1:100 - 1:250
|PBS 49%,Sodium azide 0.01%,Glycerol 50%,BSA 0.05%|
|Tissue culture supernatant (Protein A or G Sepharose)
|Is unsuitable for Flow Cyt or IP.
|Homo sapiens GRB2-associated binding protein 2 (GAB2), transcript variant 2|
|Gab2 (Grb2-associated binder-2) is an adaptor protein involved in numerous intracellular signaling pathways via its interaction with receptor tyrosine kinases (RTKs), growth factors and cytokines. Gab2 is a substrate of various RTKs, including EGFR, insulin receptor, cytokine receptors as well as B and T cell antigen receptors; Gab2 acts as a docking protein for several SH2-containing proteins (1-3). Upon tyrosine phosphorylation, Gab2 interacts with SHP2 tyrosine phosphatase and GRB2 adaptor protein PI3-kinase, CrkL and SHC (4-5).|
EGFR1 Signaling Pathway
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Western blot - GAB2 antibody [EPR2869]; All lanes : Anti-GAB2 antibody [EPR2869] at 1/1000 dilution.Lane 1 : K562 cell lysate.Lane 2 : MCF7 cell lysate.Lane 3 : TF-1 cell lysate.Lane 4 : HeLa cell lysate.Lysates/proteins at 10 µg per lane.Predicted band size : 74 kDa.
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - GAB2 antibody [EPR2869]; ab108423, at 1/100 dilution, staining GAB2 in paraffin-embedded Human stomach tissue by Immunohistochemistry.
Immunocytochemistry/ Immunofluorescence - GAB2 antibody [EPR2869]; ab108423, at 1/100 dilution, staining GAB2 in SH-SY-5Y cells by Immunofluorescence.