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Anti-GAB2 Antibody EPR2869


Specifications Citations (1) Customer Reviews Product Documents
SKU Description Amount Price Availability*  
TA307120 Rabbit monoclonal antibody against Gab2(clone EPR2869) 100ul $325 In Stock
LC415859 GAB2 HEK293T cell transient overexpression lysate (as WB positive control) 20ug $50 In Stock
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OriGene Data

ImmunogenA synthetic peptide corresponding to residues in human Gab2 was used as an immunogen.
Clone NameEPR2869 IsotypeIgG
Species ReactivityMouse, Rat, Human ConcentrationLot dependent; please refer to CoA along with shipment
Guaranteed Application *WB, IHC, IF Suggested DilutionsWB: 1:1000 - 1:10000; IHC-P: 1:100 - 1:250; ICC/IF: 1:100 - 1:250
Predicted MW Explanation 74 kDa
BufferPBS 49%,Sodium azide 0.01%,Glycerol 50%,BSA 0.05%
Purification Tissue culture supernatant
Note Is unsuitable for Flow Cyt or IP.

Reference Data

Target NameHomo sapiens GRB2-associated binding protein 2 (GAB2), transcript variant 2
Alternative NameKIAA0571
Database LinkNP_036428
Entrez Gene 9846 Human
Entrez Gene 14389 Mouse
Entrez Gene 84477 Rat
FunctionGab2 (Grb2-associated binder-2) is an adaptor protein involved in numerous intracellular signaling pathways via its interaction with receptor tyrosine kinases (RTKs), growth factors and cytokines. Gab2 is a substrate of various RTKs, including EGFR, insulin receptor, cytokine receptors as well as B and T cell antigen receptors; Gab2 acts as a docking protein for several SH2-containing proteins (1-3). Upon tyrosine phosphorylation, Gab2 interacts with SHP2 tyrosine phosphatase and GRB2 adaptor protein PI3-kinase, CrkL and SHC (4-5).
Related PathwayDruggable Genome Fc epsilon RI signaling pathwayFc gamma R-mediated phagocytosisChronic myeloid leukemia

* Availability is in business days
* OriGene provides validated application data and protocol, with money back guarantee.

WB Image
Western blot - GAB2 antibody [EPR2869]; All lanes : Anti-GAB2 antibody [EPR2869] at 1/1000 dilution.Lane 1 : K562 cell lysate.Lane 2 : MCF7 cell lysate.Lane 3 : TF-1 cell lysate.Lane 4 : HeLa cell lysate.Lysates/proteins at 10 ug per lane.Predicted band size : 74 kDa.

IHC Image
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - GAB2 antibody [EPR2869]; TA307120, at 1/100 dilution, staining GAB2 in paraffin-embedded Human stomach tissue by Immunohistochemistry.

IF Image
Immunocytochemistry/ Immunofluorescence - GAB2 antibody [EPR2869]; TA307120, at 1/100 dilution, staining GAB2 in SH-SY-5Y cells by Immunofluorescence.


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