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Anti-GAB1 Antibody Y423
Also for GAB1 (NM_002039)
|A synthetic peptide corresponding to residues in human Gab1 was used as immunogen. The antibody is predicted to detect splice isoform 2 based on sequence analysis.|
|Human, Mouse, Rat
||0.5~1.0 mg/ml (Lot Dependent)
||WB: 1: 1,000; IP: 1:50
|PBS 49%,Sodium azide 0.01%,Glycerol 50%,BSA 0.05%|
|Homo sapiens GRB2-associated binding protein 1 (GAB1), transcript variant 2|
|GRB2-associated binding protein 1|
|Gab1 (Grb2-associated binder-1) is an adaptor protein that serves to activate numerous intracellular signaling pathways via its interaction with receptor tyrosine kinases (RTKs). Gab1 is a substrate of various RTKs, including EGFR, insulin receptor, cytokine receptors, and B cell antigen receptors; and it acts as a docking protein for several SH2-containing proteins (1-3). Tyrosine-phosphorylated Gab1 may recruit cytosolic signaling proteins to the cellular membrane, where they can act on membrane-bound targets as well as activate downstream pathways (4) |
EGFR1 Signaling Pathway
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Western blot - GAB1 antibody [Y423]; Anti-GAB1 antibody [Y423] at 1/5000 dilution + 293 cell lysate.Predicted band size : 76 kDa.Observed band size : 76 kDa.
Immunofluorescence - GAB1 antibody [Y423]; TA300549 at a 1:50 dilution staining GAB1 in PC-12 cells using immunofluoresence