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Anti-GAB1 Antibody Y423


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SKU Description Amount Price Availability*  
  • Rabbit Monoclonal Antibody against GAB1 (Clone Y423)
  • Free Sample of Positive Control: HEK293T cell transient overexpression lysate (LC400746) , 20ug Explanation
100ul $325 3-7 Days
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OriGene Data

ImmunogenA synthetic peptide corresponding to residues in human Gab1 was used as immunogen. The antibody is predicted to detect splice isoform 2 based on sequence analysis.
Clone NameY423 IsotypeIgG
Species ReactivityMouse, Rat, Human ConcentrationLot dependent; please refer to CoA along with shipment
Guaranteed Application *WB, IF Suggested DilutionsWB: 1: 1,000; IP: 1:50
Predicted MW Explanation 76 kDa
BufferPBS 49%,Sodium azide 0.01%,Glycerol 50%,BSA 0.05%
Purification IgG fraction

Reference Data

Target NameHomo sapiens GRB2-associated binding protein 1 (GAB1), transcript variant 2
Alternative NameGRB2-associated binding protein 1
Database LinkNP_002030
Entrez Gene 2549 Human
Entrez Gene 14388 Mouse
Entrez Gene 361388 Rat
FunctionGab1 (Grb2-associated binder-1) is an adaptor protein that serves to activate numerous intracellular signaling pathways via its interaction with receptor tyrosine kinases (RTKs). Gab1 is a substrate of various RTKs, including EGFR, insulin receptor, cytokine receptors, and B cell antigen receptors; and it acts as a docking protein for several SH2-containing proteins (1-3). Tyrosine-phosphorylated Gab1 may recruit cytosolic signaling proteins to the cellular membrane, where they can act on membrane-bound targets as well as activate downstream pathways (4)
Related PathwayDruggable Genome ErbB signaling pathwayNeurotrophin signaling pathwayRenal cell carcinoma

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Western blot - GAB1 antibody [Y423]; Anti-GAB1 antibody [Y423] at 1/5000 dilution + 293 cell lysate.Predicted band size : 76 kDa.Observed band size : 76 kDa.
Immunofluorescence - GAB1 antibody [Y423]; TA300549 at a 1:50 dilution staining GAB1 in PC-12 cells using immunofluoresence


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