Home Antibody All anti-FYB antibodies
|ADAP antibody was raised against a 20 amino acid peptide from near the carboxy terminus of human ADAP.|
||WB: 0.5 - 1 ug/ml, ICC: 10 ug/ml, IF: 20 ug/ml
|PBS containing 0.02% sodium azide.|
|Affinity chromatography purified via peptide column
|Homo sapiens FYN binding protein (FYB), transcript variant 1|
|ADAP; PRO0823; SLAP-130; SLAP130|
Entrez Gene 2533 Human
Entrez Gene 23880 Mouse
|The adhesion and degranulation adaptor protein (ADAP) was initially identified as a molecular adapter that couples T cell receptor (TCR) stimulation to the avidity of integrins governing T cell adhesion. TCR stimulation promotes the formation of a multi-protein complex containing CARMA1, MALT1, and BCL-10, which through the association of ADAP, ultimately activates the NF-kappaB family of transcription factors. More recent experiments have shown that ADAP controls optimal T cell proliferation, cytokine production, and expression of the Bcl-2 family member Bcl-x(L), suggesting that ADAP regulates T cell activation by promoting antigen-dependent T cell-antigen presenting cell (APC) activation. At least three isoforms of ADAP are known to exist.|
|Druggable Genome |
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Western blot analysis of ADAP in K562 cell lysate with ADAP antibody at (A) 0.5 and (B) 1 ug/mL.
Immunocytochemistry of ADAP in K562 cells with ADAP antibody at 10 ug/mL.