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Anti-FYB Antibody EP2546Y


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SKU Description Amount Price Availability*  
  • Rabbit Monoclonal Antibody against FYB (Clone EP2546Y)
100ul $325 3-7 Days

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OriGene Data

ImmunogenA synthetic peptide corresponding to residues on the N-terminus of human FYB was used as an immunogen.
Clone NameEP2546Y IsotypeIgG
Species ReactivityHuman (Does not react with: Mouse, Rat) ConcentrationLot dependent; please refer to CoA along with shipment
Guaranteed Application *WB, IHC, IF Suggested DilutionsWB: 1:5000~10,000; IHC: 1:250~500; ICC: 1: 100~250; FC: 1:60
Predicted MW Explanation 85 kDa
BufferPBS 49%,Sodium azide 0.01%,Glycerol 50%,BSA 0.05%
Purification Tissue culture supernatant
Note Does not react with Mouse, Rat

Reference Data

Target NameHomo sapiens FYN binding protein (FYB), transcript variant 2
Alternative NameADAP; PRO0823; SLAP-130; SLAP130
Database LinkNP_955367
Entrez Gene 2533 Human
FunctionFYN-binding protein (FYB) is an adapter protein for Fyn and SLP-76 signaling cascades in T cells. A hematopoietic protein, FYB associates with p59fyn and becomes tyrosine-phosphorylated in response to receptor ligation. FYB has been associated to modulation of IL-2 expression in T cells and platelet activation (3). Fyn (p59Fyn) is a 59 kDa member of the Src family of tyrosine kinases. The carboxy terminus of Fyn shares extensive amino acid sequence homology with Src, but is very different within the amino-terminal 81 amino acid residues. The Fyn protein is synthesized and N-myristoylated on cytosolic polysomes and then rapidly targeted to the plasma membrane, where it is palmitoylated. Fyn's biological functions are diverse and include signaling via the T cell receptor, regulation of brain function and adhesion mediated signaling (2, 3).
Related PathwayDruggable Genome

* Availability is in business days
* OriGene provides validated application data and protocol, with money back guarantee.

Western blot - FYB antibody [EP2546Y]; Anti-FYB antibody [EP2546Y] at 1/10000 dilution + TF-1 lysate at 10 ug.Secondary.HRP labelled goat anti-rabbit at 1/2000 dilution.Predicted band size : 85 kDa.Observed band size : 110 kDa .
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - FYB antibody [EP2546Y]; TA301213, at 1/250 dilution, staining FYB in paraffin-embedded human tonsil tissue by Immunohistochemistry.
Immunocytochemistry/ Immunofluorescence - FYB antibody [EP2546Y]; ICC/If image of CHO cell expressing human ADAP using ab 76103. The cells were fixed in formaldehyde and permeabilised using 0.2% Triton X100 for 5 mins. The cells were them blocked using 10% serum for 1 hour.


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