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Home Antibody All anti-FTH1 antibodies

Anti-FTH1 Antibody EPR3005Y

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SKU Description Amount Price Availability*  
TA301281 Rabbit Monoclonal Antibody against FTH1 (Clone EPR3005Y) 100ul $325 In Stock
LC400741 FTH1 HEK293T cell transient overexpression lysate (as WB positive control) 20ug $50 In Stock
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WB(1)
IHC(4)

OriGene Data

ImmunogenA synthetic peptide corresponding to residues near the C terminus of human Ferritin (heavy chain) was used as an immunogen. This antibody recognizes only the Ferritin heavy chain.
Clone NameEPR3005Y IsotypeIgG
Species ReactivityHuman (Does not react with: Mouse, Rat) ConcentrationLot dependent; please refer to CoA along with shipment
Guaranteed Application *WB, IHC Suggested DilutionsWB: 1:500 - 1:2000; IHC-P: 1:100 - 1:250
BufferPBS 49%,Sodium azide 0.01%,Glycerol 50%,BSA 0.05%
Purification Tissue culture supernatant
Note Is unsuitable for Flow Cyt,ICC/IF or IP.

Reference Data

Target NameHomo sapiens ferritin, heavy polypeptide 1 (FTH1)
Alternative NameFHC; FTH; FTHL6; HFE5; PIG15; PLIF
Database LinkNP_002023
Entrez Gene 2495 Human
FunctionFerritin is important in iron homeostasis. It is the main iron-storage protein, composed of two partially homologous subunits, heavy and light chains. Ferritin molecules in cells containing high levels of iron tend to be rich in light chains, and may have a long-term storage function, whereas heavy-rich ferritins are more active in iron metabolism (1-2). Mutations in the ferritin gene cause the hereditary hyperferritinemia-cataract syndrome and neuroferritinopathy, associated with inflammation. Elevated levels of ferritin are reported as characteristic of adult-onset Still's disease and hemophagocytic syndrome, also associated with inflammation (3). Microfilaments and increased levels of exogenous ferritin are excreted directly into the bile by way of a second microfilament-independent, chloroquine-insensitive pathway, supporting a possible physiological mechanism for the release of ferritin from the liver (4).
Related PathwayDruggable Genome Porphyrin and chlorophyll metabolism

* Availability is in business days
* OriGene provides validated application data and protocol, with money back guarantee.

Western blot - Ferritin Heavy Chain antibody; Lanes 1 - 3 : Anti-Ferritin Heavy Chain antibody at 1:500.Lane 4 : Anti-Ferritin Heavy Chain antibody at 1:2000.Lane 5 : Anti-Ferritin Heavy Chain antibody at 1:5000.Lane 1 : Human liver lysate.Lane 2 : SH-SY5Y lysate.Lane 3 : Human brain lysate.Lane 4 : Human brain lysate.Lane 5 : HeLa cell lysate.Lysates/proteins at 10 ug per lane.Secondary.HRP labelled goat anti-rabbit at 1:2000.Predicted band size : 21 kDa.Observed band size : 21 kDa.
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Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Ferritin Heavy Chain antibody [EPR3005Y]; TA301281 at 1/100 dilution staining Ferritin Heavy Chain in human kidney tissue, using a HRP/AP polymerized secondary antibody.
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Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)-Anti-Ferritin Heavy Chain antibody [EPR3005Y](TA301281); TA301281 showing positive staining in Normal liver tissue.
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Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)-Anti-Ferritin Heavy Chain antibody [EPR3005Y](TA301281); TA301281 showing positive staining in Normal breast tissue.
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Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)-Anti-Ferritin Heavy Chain antibody [EPR3005Y](TA301281); TA301281 showing positive staining in Normal tonsil tissue.
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