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Home Antibody All anti-FTH1 antibodies

Anti-FTH1 Antibody EPR3005Y

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Specifications Citations Related Products Product Documents
SKU Description Amount Price Availability*  
TA301281
  • Rabbit Monoclonal Antibody against FTH1 (Clone EPR3005Y)
  • FREE positive control: HEK293T cell transient overexpression lysate (LC400741) , 20ug
100ul 325 In Stock
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WB(1)
IHC(4)
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Also for FTH1 (NM_002032)
cDNA Clone shRNA/siRNA Lysate Protein Antibody

OriGene Data

ImmunogenA synthetic peptide corresponding to residues near the C terminus of human Ferritin (heavy chain) was used as an immunogen. This antibody recognizes only the Ferritin heavy chain.
Clone NameEPR3005Y IsotypeTissue culture supernatant
Species ReactivityHuman Concentration0.5~1.0 mg/ml (Lot Dependent)
Guaranteed Application *WB, IHC Suggested DilutionsWB: 1:500 - 1:2000; IHC-P: 1:100 - 1:250
BufferDoes not react with Mouse, Rat. Is unsuitable for Flow Cyt,ICC/IF or IP.
Purification PBS 49%,Sodium azide 0.01%,Glycerol 50%,BSA 0.05%
Note Is unsuitable for Flow Cyt,ICC/IF or IP.

Reference Data

Target NameHomo sapiens ferritin, heavy polypeptide 1 (FTH1)
Alternative NameFHC; FTH; FTHL6; HFE5; PIG15; PLIF
Database LinkNP_002023
FunctionFerritin is important in iron homeostasis. It is the main iron-storage protein, composed of two partially homologous subunits, heavy and light chains. Ferritin molecules in cells containing high levels of iron tend to be rich in light chains, and may have a long-term storage function, whereas heavy-rich ferritins are more active in iron metabolism (1-2). Mutations in the ferritin gene cause the hereditary hyperferritinemia-cataract syndrome and neuroferritinopathy, associated with inflammation. Elevated levels of ferritin are reported as characteristic of adult-onset Still's disease and hemophagocytic syndrome, also associated with inflammation (3). Microfilaments and increased levels of exogenous ferritin are excreted directly into the bile by way of a second microfilament-independent, chloroquine-insensitive pathway, supporting a possible physiological mechanism for the release of ferritin from the liver (4).
Related Pathway

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WB Image
Western blot - Ferritin Heavy Chain antibody [EPR3005Y]; Lanes 1 - 3 : Anti-Ferritin Heavy Chain antibody [EPR3005Y] at 1/500 dilution.Lane 4 : Anti-Ferritin Heavy Chain antibody [EPR3005Y] at 1/2000 dilution.Lane 5 : Anti-Ferritin Heavy Chain antibody [EPR3005Y] at 1/5000 dilution.Lane 1 : Human liver lysate.Lane 2 : SH-SY5Y lysate.Lane 3 : Human brain lysate.Lane 4 : Human brain lysate.Lane 5 : HeLa cell lysate.Lysates/proteins at 10 µg per lane.Secondary.HRP labelled goat anti-rabbit at 1/2000 dilution.Predicted band size : 21 kDa.Observed band size : 21 kDa.
IHC Image
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Ferritin Heavy Chain antibody [EPR3005Y]; TA301281 at 1/100 dilution staining Ferritin Heavy Chain in human kidney tissue, using a HRP/AP polymerized secondary antibody.
IHC Image
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)-Anti-Ferritin Heavy Chain antibody [EPR3005Y](TA301281); TA301281 showing positive staining in Normal liver tissue.
IHC Image
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)-Anti-Ferritin Heavy Chain antibody [EPR3005Y](TA301281); TA301281 showing positive staining in Normal breast tissue.
IHC Image
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)-Anti-Ferritin Heavy Chain antibody [EPR3005Y](TA301281); TA301281 showing positive staining in Normal tonsil tissue.

 

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