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Anti-FTH1 Antibody EPR3004Y
Also for FTH1 (NM_002032)
|A synthetic peptide corresponding to residues in human Ferritin was used as an immunogen. This antibody recognizes both, Ferritin heavy and light chains.|
|Human, Mouse, Rat
||0.5~1.0 mg/ml (Lot Dependent)
||WB: 1: 1000~2000; ICC: 1: 100
|PBS 49%,Sodium azide 0.01%,Glycerol 50%,BSA 0.05%|
|Tissue culture supernatant (Protein A or G Sepharose)
|Homo sapiens ferritin, heavy polypeptide 1 (FTH1)|
|FHC; FTH; FTHL6; PIG15; PLIF|
|Ferritin is important in iron homeostasis. It is the main iron-storage protein, composed of two partially homologous subunits, heavy and light chains. Ferritin molecules in cells containing high levels of iron tend to be rich in light chains, and may have a long-term storage function, whereas heavy-rich ferritins are more active in iron metabolism (1-2). Mutations in the ferritin gene cause the hereditary hyperferritinemia-cataract syndrome and neuroferritinopathy, associated with inflammation. Elevated levels of ferritin are reported as characteristic of adult-onset Still's disease and hemophagocytic syndrome, also associated with inflammation (3). Microfilaments and increased levels of exogenous ferritin are excreted directly into the bile by way of a second microfilament-independent, chloroquine-insensitive pathway, supporting a possible physiological mechanism for the release of ferritin from the liver (4). |
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Western blot - Anti-Ferritin antibody [EPR3004Y]; All lanes : Anti-Ferritin antibody [EPR3004Y] at 1/2000 dilution.Lane 1 : Jurkat cell lysate.Lane 2 : SH-SY-5Y cell lysate.Lane 3 : Human brain lysates.Lysates/proteins at 10 µg per lane.Secondary.HRP labelled goat anti-rabbit at 1/2000 dilution.Predicted band size : 21,19 kDa.Observed band size : 19,21 kDa.