Home Antibody All anti-FRMPD2 antibodies
Also for FRMPD2 (NM_001017929)
|FRMPD2 antibody was raised against a 15 amino acid peptide from near the amino terminus of human FRMPD2.|
|Human, Mouse, Rat
||WB: 1 - 2 ug/ml
|PBS containing 0.02% sodium azide.|
|Affinity chromatography purified via peptide column
|Homo sapiens FERM and PDZ domain containing 2 (FRMPD2), transcript variant 2|
|MGC35285; MGC87776; MGC87777; MGC90186; PDZD5C; PDZK5C; MGC87776; MGC87777; MGC90186; PDZD5C; PDZK5C; PDZ domain containing 5C; FERM and PDZ domain containing 2|
Entrez Gene 143162 Human
Entrez Gene 498583 Rat
|The FERM and PDZ domain containing (FRMPD) protein family consists of four proteins that contain a FERM (Four-point-one, erzin, radixin, moesin) domain and at least one PDZ (PSD-95/Discs large/Zonula-occuldens-1) domain. FRMPD2 also contains an N-terminal KIND domain and three PDZ domains and is structurally similar to the protein tyrosine phosphatase PTP-BL (4). FRMPD2 is localized in a polarized fashion in epithelial cells at the basolateral membrane and partially co-localizes with the tight-junction marker protein Zonula-occuldens-1. Suppression of FRMPD2 expression via RNAi in Caco-2 cells results in an impairment of tight junction formation, indicating that FRMPD2 plays a major role in tight junction formation. Other experiments indicate that FRMPD2 is a binding partner to several catenin family members and recruitment of FRMPD2 to cell-cell contacts is dependent on E-cadherin-mediated cell-cell adhesion.|
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Western blot analysis of FRMPD2 in rat kidney tissue lysate with FRMPD2 antibody at (A) 1 and (B) 2 µg/ml.
Immunohistochemistry of FRMPD2 in mouse kidney tissue with FRMPD2 antibody at 5 ug/ml.