Anti-FOXO4 Antibody, EPR2150(3)

Also for FOXO4 (NM_001170931)

OriGene Data

Immunogen	A synthetic peptide corresponding to residues in human FOXO4 was used as an immunogen.
Clone Name	EPR2150(3)	Isotype
Species Reactivity	Human	Concentration
Guaranteed Application *	WB, IHC	Suggested Dilutions	WB: 1:10,000 - 50,000; IHC 1:250 - 500; ICC: 1:100 - 250; IP: 1:10 - 100;
Buffer	Store at -20 °C. Buffer: Antibody buffer, sodium azide, glycerol, and BSA. Stable for 12 months from date of receipt.
Purification	(Protein A or G Sepharose)

Reference Data

Target Name	Homo sapiens forkhead box O4 (FOXO4), transcript variant 2
Alternative Name	AFX; AFX1; MLLT7
Database Link	NP_001164402
Function	FOXO4 is a member of the O class of winged helix/forkhead transcription factor family. It is regulated by factors involved in growth and differentiation indicating they play a role in these processes. A translocation involving this protein on chromosome X and the homolog of the Drosophila trithorax gene, encoding a DNA binding protein, located on chromosome 11 is associated with leukemia (1). A constitutively active FOXO4 mutant where phosphorylation sites Thr-32, Ser-187 and Ser-262 have been mutated to alanine may have therapeutic potential in ERBB2/HER2-overexpressing cancers as it inhibits ERBB2-mediated cell survival, transformation and tumorigenicity (2).
Related Pathway	TGF Beta Signaling Pathway

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WB Image

Western blot analysis on (A) HA-FOXO4 transfected 293T, (B) HA-FOXO4.A3 (T32, S197 and S262 mutated to A) transfected 293T, and (C) 293T cell lysates using anti-FOXO4 RabMAb.

IHC Image

Immunohistochemical analysis of paraffin-embedded human placenta tissue using anti-FOXO4 RabMAb.

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OriGene provides conjugation services of TrueMAB antibodies with the following molecules:

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OriGene offers bulk sizes of TrueMAB antibodies in both the BSA/glycerol formulation and the carrier-free (BSA/glycerol-free) formulation.

Anti-FOXO4 Antibody EPR2150(3)

TrueMAB™ Antibodies - Made against Authentic Protein Antigens

OriGene Data

Reference Data