Home All anti-FOXO4 antibodies
Anti-FOXO4 Antibody EPR2150(3)
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Also for FOXO4 (NM_001170931)
|A synthetic peptide corresponding to residues in human FOXO4 was used as an immunogen.|
||WB: 1:10,000 - 50,000; IHC 1:250 - 500; ICC: 1:100 - 250; IP: 1:10 - 100;
|Store at -20 °C. Buffer: Antibody buffer, sodium azide, glycerol, and BSA. Stable for 12 months from date of receipt.|
|Homo sapiens forkhead box O4 (FOXO4), transcript variant 2|
|AFX; AFX1; MLLT7|
|FOXO4 is a member of the O class of winged helix/forkhead transcription factor family. It is regulated by factors involved in growth and differentiation indicating they play a role in these processes. A translocation involving this protein on chromosome X and the homolog of the Drosophila trithorax gene, encoding a DNA binding protein, located on chromosome 11 is associated with leukemia (1). A constitutively active FOXO4 mutant where phosphorylation sites Thr-32, Ser-187 and Ser-262 have been mutated to alanine may have therapeutic potential in ERBB2/HER2-overexpressing cancers as it inhibits ERBB2-mediated cell survival, transformation and tumorigenicity (2).|
TGF Beta Signaling Pathway
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Western blot analysis on (A) HA-FOXO4 transfected 293T, (B) HA-FOXO4.A3 (T32, S197 and S262 mutated to A) transfected 293T, and (C) 293T cell lysates using anti-FOXO4 RabMAb.
Immunohistochemical analysis of paraffin-embedded human placenta tissue using anti-FOXO4 RabMAb.