Home Antibody All anti-FOXO1 antibodies
Anti-FOXO1 Antibody Polyclonal
Also for FOXO1 (NM_002015)
|FOXO1 antibody was raised against a 15 amino acid synthetic peptide near the amino terminus of human FOXO1.|
|Human, Mouse, Rat
||ELISA, WB: 1 ug/ml, ICC: 4 ug/ml, IF: 20 ug/ml
|FOXO1 Antibody is supplied in PBS containing 0.02% sodium azide.|
|FOXO1 Antibody is affinity chromatography purified via peptide column.
|Homo sapiens forkhead box O1 (FOXO1)|
|FKH1; FKHR; FOXO1A|
Entrez Gene 2308 Human
Entrez Gene 56458 Mouse
Entrez Gene 84482 Rat
|FOXO1 Antibody: FOXO1, also known as FKHR or ForkHead in Rhabdomyosarcoma, is a 70 kDa protein which is a ubiquitously expressed member of a subfamily of the forkhead homeotic gene family of transcription factors and shuttles between the cytoplasm and nucleus. FOXO transcription factors are key players of cell fate decisions, metabolism, stress resistance, tumor suppression and are regulated by growth factors, oxidative stress or nutrient deprivation. In insulin-responsive tissues, stress or nutrient abundance triggers phosphorylation by PKB/AKT, blocking nuclear translocation and activity. Genetic mutations involving FOXO1A are a cause of alveolar rhabdomyosarcoma (RMS2). Recent studies link the anti-tumor activity of FOXO1 and the process of autophagy.|
|Transcription FactorsDruggable Genome Insulin signaling pathwayPathways in cancerProstate cancer|
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Western blot analysis of FOXO1 in Hela cell lysate with FOXO1 antibody at 1 ug/mL.
Immunocytochemistry of FOXO1 in HeLa cells with FOXO1 antibody at 4 ug/mL.